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Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate

Also known as: Urogesic Blue

Route: Oral

Check Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate Interactions →

8 interactions on record

Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate has 8 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetazolamide, Ketoconazole, Opioid Analgesics. Patients taking Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 8
Major: 3
Moderate: 5

Major (3)

Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate + Acetazolamide— These drugs may precipitate with formaldehyde in the urine, increasing the danger of crystalluria.
Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate + Ketoconazole— Drug Interactions because of this product's effect on gastrointestinal motility and gastric emptying, it may decrease th…
Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate + Opioid Analgesics— May result in increased risk of severe constipation.

Moderate (5)

Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate + Andthiazide— May cause urine to become alkaline, reducing effectiveness of methenamine by inhibiting its conversion to formaldehyde.
Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate + Antacids Containing Calcium— May reduce absorption of hyoscyamine and cause urine to become alkaline, reducing methenamine effectiveness. Doses shoul…
Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate + Antiperistaltic Antidiarrheal Drugs— May reduce absorption of hyoscyamine due to effects on GI motility. Doses should be spaced 1 hour apart.
Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate + Monoamine Oxidase Inhibitors (Maois)— Concurrent use may intensify antimuscarinic side effects.
Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate + Urinary Alkalinizing Agents— May cause urine to become alkaline, reducing effectiveness of methenamine by inhibiting its conversion to formaldehyde.

Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate + Acetazolamide⚠️Major

These drugs may precipitate with formaldehyde in the urine, increasing the danger of crystalluria.

Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate + Ketoconazole⚠️Major

Drug Interactions because of this product's effect on gastrointestinal motility and gastric emptying, it may decrease the absorption of other oral medications during concurrent use such as: urinary alkalizers; thiazide diuretics (may cause the urine to become alkaline reducing the effectiveness of methenamine by inhibiting its conversion to formaldehyde); antimuscarinics (concurrent use may intensify antimuscarinic effects of hyoscyamine because of secondary antimuscarinic activities of these medications); antacids/antidiarrheals (may reduce absorption of hyoscyamine, concurrent use with antacids may cause urine to become alkaline reducing effectiveness of methenamine by inhibiting its conversion to formaldehyde) doses of these medications should be spaced 1 hour apart from doses of hyoscyamine; antimyasthenics (concurrent use with hyoscyamine may further reduce intestinal motility); ketoconazole (patients should be advised to take this combination at least 2 hours after ketoconazole); monoamine oxidase (MAO) Inhibitors (concurrent use may intensify antimuscarinic side effects, opoid (narcotic) analgesics may result in increased risk of severe constipation); sulfonamides (these drugs may precipitate with formaldehyde in the urine, increasing the danger of crystalluria).

Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate + Opioid Analgesics⚠️Major

May result in increased risk of severe constipation.

Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate + Andthiazide🟡Moderate

May cause urine to become alkaline, reducing effectiveness of methenamine by inhibiting its conversion to formaldehyde.

Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate + Antacids Containing Calcium🟡Moderate

May reduce absorption of hyoscyamine and cause urine to become alkaline, reducing methenamine effectiveness. Doses should be spaced 1 hour apart.

Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate + Antiperistaltic Antidiarrheal Drugs🟡Moderate

May reduce absorption of hyoscyamine due to effects on GI motility. Doses should be spaced 1 hour apart.

Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate + Monoamine Oxidase Inhibitors (Maois)🟡Moderate

Concurrent use may intensify antimuscarinic side effects.

Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate + Urinary Alkalinizing Agents🟡Moderate

May cause urine to become alkaline, reducing effectiveness of methenamine by inhibiting its conversion to formaldehyde.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.