Trazodone has 20 known drug interactions based on U.S. FDA drug labeling data. 12 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amiodarone Hydrochloride, Atropa Belladonna And Opium, Hydrocodone Bitartrate And Acetaminophen. Patients taking Trazodone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 20
- Major
- 12
- Moderate
- 7
Major (12)
- Trazodone + Amiodarone Hydrochloride— Antidepressant metabolized by CYP3A. QT interval prolongation and torsades de pointes reported with coadministration.
- Trazodone + Atropa Belladonna And Opium— Concomitant use may result in serotonin syndrome. Patient requires careful observation, particularly during initiation a…
- Trazodone + Hydrocodone Bitartrate And Acetaminophen— Concomitant use has resulted in serotonin syndrome; carefully observe patient during treatment initiation and dose adjus…
- Trazodone + Hydromorphone Hydrochloride— Concomitant use may result in serotonin syndrome. Frequently evaluate patient during treatment initiation and dose adjus…
- Trazodone + Levorphanol Tartrate— Concomitant use has resulted in serotonin syndrome.
- Trazodone + Metaxalone— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modif…
- Trazodone + Morphine Sulfate— Concomitant use can result in serotonin syndrome. Requires frequent patient evaluation, particularly during initiation a…
- Trazodone + Nalbuphine Hydrochloride— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dose adjustm…
- Trazodone + Oxymorphone Hydrochloride— Serotonergic drug that may result in serotonin syndrome when used concomitantly.
- Trazodone + Pentazocine Hydrochloride And Naloxone Hydrochloride— Concomitant use has resulted in serotonin syndrome. Carefully observe patient during treatment initiation and dose adjus…
- Trazodone + Remifentanil Hydrochloride— Concomitant use may result in serotonin syndrome.
- Trazodone + Tapentadol Hydrochloride— Concomitant use may result in serotonin syndrome. Frequent patient evaluation is recommended during initiation and dose …
Moderate (7)
- Trazodone + Buspirone Hydrochloride— One report suggested concomitant use may cause 3-6 fold elevations in ALT; however, similar study found no interactive e…
- Trazodone + Butorphanol Tartrate— Concomitant use may result in serotonin syndrome; monitor regularly during initiation and dose adjustment.
- Trazodone + Carbamazepine— CYP3A4 inhibitor that increases carbamazepine plasma levels. Close monitoring of carbamazepine levels and dosage adjustm…
- Trazodone + Fosphenytoin Sodium— May increase phenytoin serum levels; monitoring of phenytoin levels recommended.
- Trazodone + Lasmiditan— Increased risk of serotonin syndrome when combined with lasmiditan; use with caution.
- Trazodone + Phenytoin— May increase phenytoin serum levels; monitoring of phenytoin levels recommended.
- Trazodone + Phenytoin Sodium— May increase phenytoin serum levels; monitoring of phenytoin levels recommended.