Tcas has 18 known drug interactions based on U.S. FDA drug labeling data. 16 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cyclobenzaprine, Cyclobenzaprine Hcl Er, Cyclobenzaprine Hydrochloride. Patients taking Tcas should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 18
- Major
- 16
- Moderate
- 2
Major (16)
- Tcas + Cyclobenzaprine— Postmarketing cases of serotonin syndrome reported during combined use; careful observation advised.
- Tcas + Cyclobenzaprine Hcl Er— Postmarketing cases of serotonin syndrome reported during combined use with tricyclic antidepressants.
- Tcas + Cyclobenzaprine Hydrochloride— Serotonin syndrome reported; may enhance seizure risk when combined with tramadol.
- Tcas + Eletriptan Hydrobromide— Tricyclic antidepressants may cause serotonin syndrome when co-administered with eletriptan.
- Tcas + Fluoxetine— Fluoxetine is a potent CYP2D6 inhibitor that increases TCA levels. Monitor TCA levels during coadministration and after …
- Tcas + Fluoxetine Hydrochloride— Monitor TCA levels during coadministration with fluoxetine or when fluoxetine has been recently discontinued.
- Tcas + Frovatriptan Succinate— Combined use of frovatriptan with tricyclic antidepressants has been reported to cause serotonin syndrome.
- Tcas + Hydromorphone Hydrochloride— Concomitant use may result in serotonin syndrome. Frequently evaluate patient during treatment initiation and dose adjus…
- Tcas + Metaxalone— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modif…
- Tcas + Morphine Sulfate— Concomitant use with opioids has resulted in serotonin syndrome.
- Tcas + Naratriptan— Cases of serotonin syndrome reported with co-administration of triptans and tricyclic antidepressants. Risk of serious s…
- Tcas + Oxymorphone Hydrochloride— Concomitant use can result in serotonin syndrome.
- Tcas + Remifentanil Hydrochloride— Concomitant use may result in serotonin syndrome.
- Tcas + Sumatriptan— Serotonin syndrome cases reported during coadministration of sumatriptan and tricyclic antidepressants. Monitor for sero…
- Tcas + Sumatriptan Succinate— Serotonin syndrome reported with coadministration of sumatriptan and tricyclic antidepressants.
- Tcas + Tapentadol Hydrochloride— Concomitant use may result in serotonin syndrome.
Moderate (2)
- Tcas + Lasmiditan— Increased risk of serotonin syndrome when combined with lasmiditan; use with caution.
- Tcas + Olanzapine And Fuoxetine— Monitor TCA levels during coadministration or when olanzapine and fluoxetine capsules have been recently discontinued.