Tcas Interactions

Postmarketing cases of serotonin syndrome reported during combined use; careful observation advised.

Source: NLP:cyclobenzaprine

Serotonin syndrome reported; may enhance seizure risk when combined with tramadol.

Source: NLP:cyclobenzaprine hydrochloride

Tricyclic antidepressants may cause serotonin syndrome when co-administered with eletriptan.

Source: NLP:eletriptan hydrobromide

Fluoxetine is a potent CYP2D6 inhibitor that increases TCA levels. Monitor TCA levels during coadministration and after fluoxetine discontinuation.

Source: NLP:fluoxetine

Monitor TCA levels during coadministration with fluoxetine or when fluoxetine has been recently discontinued.

Source: NLP:fluoxetine hydrochloride

Concomitant use may result in serotonin syndrome. Frequently evaluate patient during treatment initiation and dose adjustment.

Source: NLP:hydromorphone hydrochloride

Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modification; discontinue metaxalone if serotonin syndrome occurs.

Source: NLP:metaxalone

Concomitant use with opioids has resulted in serotonin syndrome.

Source: NLP:morphine sulfate

Concomitant use can result in serotonin syndrome.

Source: NLP:oxymorphone hydrochloride

Concomitant use may result in serotonin syndrome.

Source: NLP:remifentanil hydrochloride

Serotonin syndrome cases reported during coadministration of sumatriptan and tricyclic antidepressants. Monitor for serotonin syndrome symptoms.

Source: NLP:sumatriptan

Serotonin syndrome reported with coadministration of sumatriptan and tricyclic antidepressants.

Source: NLP:sumatriptan succinate

Increased risk of serotonin syndrome when combined with lasmiditan; use with caution.

Source: NLP:lasmiditan

Monitor TCA levels during coadministration or when olanzapine and fluoxetine capsules have been recently discontinued.

Source: NLP:olanzapine and fluoxetine