Vilazodone Hydrochloride has 20 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Linezolid, Methylene Blue, Monoamine Oxidase Inhibitors (Maois). Patients taking Vilazodone Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 20
- Contraindicated
- 3
- Moderate
- 17
Contraindicated (3)
- Vilazodone Hydrochloride + Linezolid— MAOI that increases risk of serotonin syndrome when combined with vilazodone hydrochloride.
- Vilazodone Hydrochloride + Methylene Blue— Intravenous MAOI that increases risk of serotonin syndrome when combined with vilazodone hydrochloride.
- Vilazodone Hydrochloride + Monoamine Oxidase Inhibitors (Maois)— Concomitant use increases risk of serotonin syndrome. Vilazodone hydrochloride is contraindicated in patients taking MAO…
Moderate (17)
- Vilazodone Hydrochloride + Acidifying Agents— Concurrent use may potentiate bleeding risk. Inform patients of increased bleeding risk.
- Vilazodone Hydrochloride + Amphetamine— Serotonergic drugs that increase risk of serotonin syndrome; monitor patients for signs and symptoms during initiation.
- Vilazodone Hydrochloride + Buspirone— Serotonergic drug that increases risk of serotonin syndrome; monitor patients for signs and symptoms during initiation.
- Vilazodone Hydrochloride + Carbamazepine— Strong CYP3A4 inducer that decreases vilazodone exposure; consider increasing dose by 2-fold up to 80 mg daily.
- Vilazodone Hydrochloride + Clarithromycin— Strong CYP3A4 inhibitor that increases vilazodone exposure; dose should not exceed 20 mg once daily.
- Vilazodone Hydrochloride + Digoxin— Concomitant use of vilazodone increased digoxin concentrations. Monitor due to narrow therapeutic index of digoxin.
- Vilazodone Hydrochloride + Itraconazole— Strong CYP3A4 inhibitor that increases vilazodone exposure; dose should not exceed 20 mg once daily.
- Vilazodone Hydrochloride + Lithium— Serotonergic drug that increases risk of serotonin syndrome; monitor patients for signs and symptoms during initiation.
- Vilazodone Hydrochloride + Oral Anticoagulants— Concurrent use may potentiate bleeding risk. Monitor INR carefully for warfarin.
- Vilazodone Hydrochloride + Other Anticholinergic Agents— Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms, particularly during initi…
- Vilazodone Hydrochloride + Phenytoin— Strong CYP3A4 inducer that decreases vilazodone exposure; consider increasing dose by 2-fold up to 80 mg daily.
- Vilazodone Hydrochloride + Rifampin— Strong CYP3A4 inducer that decreases vilazodone exposure; consider increasing dose by 2-fold up to 80 mg daily.
- Vilazodone Hydrochloride + St. John'S Wort— Serotonergic drug that increases risk of serotonin syndrome; monitor patients for signs and symptoms during initiation.
- Vilazodone Hydrochloride + Triptans— Serotonergic drugs that increase risk of serotonin syndrome; monitor patients for signs and symptoms during initiation.
- Vilazodone Hydrochloride + Tryptophan— Serotonergic drug that increases risk of serotonin syndrome; monitor patients for signs and symptoms during initiation.
- Vilazodone Hydrochloride + Voriconazole— Strong CYP3A4 inhibitor that increases vilazodone exposure; dose should not exceed 20 mg once daily.
- Vilazodone Hydrochloride + Warfarin— Anticoagulant that may have potentiated bleeding risk; carefully monitor INR when initiating, titrating, or discontinuin…