Sedative-Hypnotics has 16 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Calcium, Magnesium, Potassium, And Sodium Oxybates, Sodium Oxybate, Butalbital, Acetaminophen And Caffeine. Patients taking Sedative-Hypnotics should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 16
- Contraindicated
- 2
- Major
- 7
- Moderate
- 5
- Minor
- 2
Contraindicated (2)
- Sedative-Hypnotics + Calcium, Magnesium, Potassium, And Sodium Oxybates— XYWAV is contraindicated for use in combination with sedative hypnotics due to potentiation of CNS-depressant effects.
- Sedative-Hypnotics + Sodium Oxybate— Sodium oxybate oral solution is contraindicated for use in combination with sedative hypnotics due to potentiation of CN…
Major (7)
- Sedative-Hypnotics + Butalbital, Acetaminophen And Caffeine— Sedative-hypnotics may enhance effects causing increased CNS depression.
- Sedative-Hypnotics + Butalbital, Aspirin, And Caffeine— Butalbital causes increased CNS depression when combined with sedative-hypnotics.
- Sedative-Hypnotics + Levorphanol Tartrate— Additive CNS depression increasing risk of hypotension, respiratory depression, profound sedation, coma, and death.
- Sedative-Hypnotics + Lorazepam— Produces increased CNS-depressant effects including respiratory depression and sedation.
- Sedative-Hypnotics + Oxycodone Hydrochloride— Additive CNS depression with potential respiratory depression, hypotension, profound sedation, or coma. Dose reduction r…
- Sedative-Hypnotics + Pentazocine Hydrochloride And Naloxone Hydrochloride— Concomitant use increases risk of hypotension, respiratory depression, profound sedation, coma, and death due to additiv…
- Sedative-Hypnotics + Temazepam— Produces additive CNS-depressant effects when co-administered with temazepam.
Moderate (5)
- Sedative-Hypnotics + Acetaminophen And Codeine Phosphate— May enhance CNS depressant effects, causing increased CNS depression.
- Sedative-Hypnotics + Butalbital And Acetaminophen— Sedative-hypnotics may enhance the effects of butalbital and acetaminophen, causing increased CNS depression.
- Sedative-Hypnotics + Butalbital And Acetaminophen Tablets— Sedative-hypnotics may have enhanced effects when combined with butalbital and acetaminophen, causing increased CNS depr…
- Sedative-Hypnotics + Butalbital, Acetaminophen, And Caffeine Capsules— Sedative-hypnotics may enhance CNS depressant effects, causing increased CNS depression.
- Sedative-Hypnotics + Hydromorphone Hydrochloride— Additive CNS depressant effects; reduced dosage of hydromorphone recommended to avoid excessive effects.
Minor (2)
- Sedative-Hypnotics + Montelukast— No dose adjustment needed when co-administered with montelukast sodium.
- Sedative-Hypnotics + Montelukast Sodium— No dose adjustment needed when co-administered with montelukast sodium.