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Tryptophan

32 interactions on record

Tryptophan has 32 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 21 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Escitalopram Oxalate, Venlafaxine Hcl Er, Venlafaxine Hydrochloride. Patients taking Tryptophan should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 32
Contraindicated: 3
Major: 21
Moderate: 8

Contraindicated (3)

Tryptophan + Escitalopram Oxalate— Concomitant use with tryptophan is not recommended due to risk of serotonin syndrome.
Tryptophan + Venlafaxine Hcl Er— Concomitant use of venlafaxine with tryptophan supplements are not recommended due to risk of serotonin syndrome.
Tryptophan + Venlafaxine Hydrochloride— Concomitant use not recommended due to serotonergic effects.

Major (21)

Tryptophan + Amphetamine Sulfate— Serotonergic drug that increases risk of serotonin syndrome when used concomitantly with amphetamine sulfate.
Tryptophan + Citalopram— Concomitant use increases risk of serotonin syndrome.
Tryptophan + Citalopram Hydrobromide— Concomitant use increases risk of serotonin syndrome. Monitor for signs and symptoms, particularly during initiation and…
Tryptophan + Desvenlafaxine Succinate— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
Tryptophan + Dextroamphetamine— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and discontinue if serotonin syndrome occurs.
Tryptophan + Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate— Serotonergic drug that increases risk of serotonin syndrome when combined with amphetamines. Initiate with lower doses a…
Tryptophan + Dextroamphetamine Sulfate— Serotonergic drug increasing risk of serotonin syndrome with dextroamphetamine sulfate.
Tryptophan + Escitalopram— Concomitant use with tryptophan is not recommended due to risk of serotonin syndrome.
Tryptophan + Fluoxetine— Concomitant use with fluoxetine increases the risk of serotonin syndrome.
Tryptophan + Fluoxetine Hydrochloride— Concomitant use increases risk of serotonin syndrome; monitor for symptoms.
Tryptophan + Fluvoxamine Maleate— Severe vomiting with coadministration.
Tryptophan + Milnacipran Hydrochloride— Concomitant use can result in serotonin syndrome. Careful monitoring advised.
Tryptophan + Mirtazapine— Concomitant use increases risk of serotonin syndrome. Monitor for signs and symptoms, particularly during initiation and…
Tryptophan + Paroxetine— Concomitant use increases risk of serotonin syndrome.
Tryptophan + Paroxetine Hydrochloride Hemihydrate— Concomitant use may cause serotonin syndrome with adverse effects including headache, nausea, sweating, and dizziness. C…
Tryptophan + Sertraline— Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms, particularly during initi…
Tryptophan + Sertraline Hydrochloride— Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms, particularly during treat…
Tryptophan + Trazodone Hydrochloride— Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms during trazodone initiatio…
Tryptophan + Ziprasidone— Risk of serotonin syndrome with concomitant therapy with tryptophan.
Tryptophan + Ziprasidone Hcl— Risk of serotonin syndrome with concomitant serotonergic therapy including tryptophan.
Tryptophan + Ziprasidone Mesylate— Risk of serotonin syndrome with concomitant serotonergic therapy including tryptophan.

Moderate (8)

Tryptophan + Desvenlafaxine— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
Tryptophan + Desvenlafaxine Er— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
Tryptophan + Duloxetine— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms during treatment initiation and dose increase…
Tryptophan + Levomilnacipran Hydrochloride— Serotonergic drug that increases risk of serotonin syndrome. Monitor for symptoms and discontinue if serotonin syndrome …
Tryptophan + Paroxetine Hydrochloride— Concomitant use of serotonergic drugs with paroxetine increases the risk of serotonin syndrome. Monitor for symptoms.
Tryptophan + Venlafaxine— Concomitant use with tryptophan supplements not recommended due to serotonin syndrome risk.
Tryptophan + Vilazodone Hydrochloride— Serotonergic drug that increases risk of serotonin syndrome; monitor patients for signs and symptoms during initiation.
Tryptophan + Vortioxetine— Serotonergic drug that increases risk of serotonin syndrome when used with TRINTELLIX. Monitor for serotonin syndrome sy…

Tryptophan + Escitalopram Oxalate⛔Contraindicated

Concomitant use with tryptophan is not recommended due to risk of serotonin syndrome.

Tryptophan + Venlafaxine Hcl Er⛔Contraindicated

Concomitant use of venlafaxine with tryptophan supplements are not recommended due to risk of serotonin syndrome.

Tryptophan + Venlafaxine Hydrochloride⛔Contraindicated

Concomitant use not recommended due to serotonergic effects.

Tryptophan + Amphetamine Sulfate⚠️Major

Serotonergic drug that increases risk of serotonin syndrome when used concomitantly with amphetamine sulfate.

Tryptophan + Citalopram⚠️Major

Concomitant use increases risk of serotonin syndrome.

Tryptophan + Citalopram Hydrobromide⚠️Major

Concomitant use increases risk of serotonin syndrome. Monitor for signs and symptoms, particularly during initiation and dosage increases.

Tryptophan + Desvenlafaxine Succinate⚠️Major

Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syndrome occurs.

Tryptophan + Dextroamphetamine⚠️Major

Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and discontinue if serotonin syndrome occurs.

Tryptophan + Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate⚠️Major

Serotonergic drug that increases risk of serotonin syndrome when combined with amphetamines. Initiate with lower doses and monitor for serotonin syndrome signs.

Tryptophan + Dextroamphetamine Sulfate⚠️Major

Serotonergic drug increasing risk of serotonin syndrome with dextroamphetamine sulfate.

Tryptophan + Escitalopram⚠️Major

Concomitant use with tryptophan is not recommended due to risk of serotonin syndrome.

Tryptophan + Fluoxetine⚠️Major

Concomitant use with fluoxetine increases the risk of serotonin syndrome.

Tryptophan + Fluoxetine Hydrochloride⚠️Major

Concomitant use increases risk of serotonin syndrome; monitor for symptoms.

Tryptophan + Fluvoxamine Maleate⚠️Major

Severe vomiting with coadministration.

Tryptophan + Milnacipran Hydrochloride⚠️Major

Concomitant use can result in serotonin syndrome. Careful monitoring advised.

Tryptophan + Mirtazapine⚠️Major

Concomitant use increases risk of serotonin syndrome. Monitor for signs and symptoms, particularly during initiation and dose increases.

Tryptophan + Paroxetine⚠️Major

Concomitant use increases risk of serotonin syndrome.

Tryptophan + Paroxetine Hydrochloride Hemihydrate⚠️Major

Concomitant use may cause serotonin syndrome with adverse effects including headache, nausea, sweating, and dizziness. Concomitant use is not recommended.

Tryptophan + Sertraline⚠️Major

Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms, particularly during initiation and dosage increases.

Tryptophan + Sertraline Hydrochloride⚠️Major

Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms, particularly during treatment initiation and dosage increases.

Tryptophan + Trazodone Hydrochloride⚠️Major

Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms during trazodone initiation.

Tryptophan + Ziprasidone⚠️Major

Risk of serotonin syndrome with concomitant therapy with tryptophan.

Tryptophan + Ziprasidone Hcl⚠️Major

Risk of serotonin syndrome with concomitant serotonergic therapy including tryptophan.

Tryptophan + Ziprasidone Mesylate⚠️Major

Risk of serotonin syndrome with concomitant serotonergic therapy including tryptophan.

Tryptophan + Desvenlafaxine🟡Moderate

Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syndrome occurs.

Tryptophan + Desvenlafaxine Er🟡Moderate

Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syndrome occurs.

Tryptophan + Duloxetine🟡Moderate

Concomitant use increases risk of serotonin syndrome. Monitor for symptoms during treatment initiation and dose increases.

Tryptophan + Levomilnacipran Hydrochloride🟡Moderate

Serotonergic drug that increases risk of serotonin syndrome. Monitor for symptoms and discontinue if serotonin syndrome occurs.

Tryptophan + Paroxetine Hydrochloride🟡Moderate

Concomitant use of serotonergic drugs with paroxetine increases the risk of serotonin syndrome. Monitor for symptoms.

Tryptophan + Venlafaxine🟡Moderate

Concomitant use with tryptophan supplements not recommended due to serotonin syndrome risk.

Tryptophan + Vilazodone Hydrochloride🟡Moderate

Serotonergic drug that increases risk of serotonin syndrome; monitor patients for signs and symptoms during initiation.

Tryptophan + Vortioxetine🟡Moderate

Serotonergic drug that increases risk of serotonin syndrome when used with TRINTELLIX. Monitor for serotonin syndrome symptoms.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.