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Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate

Also known as: Joyeaux

Check Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate Interactions →

48 interactions on record⛔ Black Box Warning

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate has 48 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Dasabuvir, Ombitasvir/Paritaprevir/Ritonavir, Acetaminophen. Patients taking Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 48
Contraindicated: 2
Moderate: 43

Contraindicated (2)

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Dasabuvir— Do not co-administer (when used with ombitasvir/paritaprevir/ritonavir) due to potential for ALT elevations.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Ombitasvir/Paritaprevir/Ritonavir— Do not co-administer due to potential for ALT elevations.

Moderate (43)

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Acetaminophen— Acetaminophen may increase plasma ethinyl estradiol levels.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Amprenavir— HIV protease inhibitor (with ritonavir) may significantly decrease plasma concentrations of estrogen and/or progestin.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Aprepitant— Induces CYP3A4, may decrease plasma concentrations of COCs and diminish effectiveness or increase breakthrough bleeding.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Ascorbic Acid— Ascorbic acid may increase plasma ethinyl estradiol levels.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Atazanavir— HIV protease inhibitor (with ritonavir) may significantly increase plasma concentrations of estrogen and/or progestin.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Atorvastatin— Co-administration increases AUC values for ethinyl estradiol by approximately 20%.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Barbiturates— Barbiturates induce CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough bleed…
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Boceprevir— HCV protease inhibitor that may decrease plasma concentrations of estrogen and/or progestin.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Bosentan— Bosentan induces CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough bleeding…
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Carbamazepine— Carbamazepine induces CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough ble…
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Colesevelam— Bile acid sequestrant significantly decreases AUC of ethinyl estradiol; effect reduced when given 4 hours apart.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Cyclosporine— COCs containing ethinyl estradiol may inhibit the metabolism of cyclosporine.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Darunavir— HIV protease inhibitor (with ritonavir) may significantly decrease plasma concentrations of estrogen and/or progestin.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Efavirenz— Non-nucleoside reverse transcriptase inhibitor that may decrease plasma concentrations of estrogen and/or progestin.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Etravirine— Non-nucleoside reverse transcriptase inhibitor may significantly increase plasma concentrations of estrogen and/or proge…
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Felbamate— Felbamate induces CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough bleedin…
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Fluconazole— CYP3A4 inhibitor may increase plasma hormone concentrations.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Fosamprenavir— HIV protease inhibitor (with ritonavir) may significantly decrease plasma concentrations of estrogen and/or progestin.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Grapefruit Juice— CYP3A4 inhibitor may increase plasma hormone concentrations.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Griseofulvin— Griseofulvin induces CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough blee…
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Indinavir— HIV protease inhibitor may significantly increase plasma concentrations of estrogen and/or progestin.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Itraconazole— CYP3A4 inhibitor itraconazole may increase plasma hormone levels.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Ketoconazole— CYP3A4 inhibitor ketoconazole may increase plasma hormone levels.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Lamotrigine— COCs have been shown to significantly decrease plasma concentrations of lamotrigine.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Lopinavir— HIV protease inhibitor (with ritonavir) may significantly decrease plasma concentrations of estrogen and/or progestin.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Lopinavir And Ritonavir— HIV protease inhibitor combination that may decrease plasma concentrations of estrogen and/or progestin.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Nelfinavir— HIV protease inhibitor may significantly decrease plasma concentrations of estrogen and/or progestin.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Nevirapine— Non-nucleoside reverse transcriptase inhibitor may significantly decrease plasma concentrations of estrogen and/or proge…
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Oxcarbazepine— Oxcarbazepine induces CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough ble…
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Phenytoin— Phenytoin induces CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough bleedin…
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Prednisolone— COCs containing ethinyl estradiol may inhibit the metabolism of prednisolone.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Rifabutin— Induces CYP3A4, may decrease plasma concentrations of COCs and diminish effectiveness or increase breakthrough bleeding.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Rifampin— Rifampin induces CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough bleeding…
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Ritonavir— HIV protease inhibitor may significantly decrease plasma concentrations of estrogen and/or progestin.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Rosuvastatin— Increases AUC values for ethinyl estradiol by approximately 20-25%.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Rufinamide— Induces CYP3A4, may decrease plasma concentrations of COCs and diminish effectiveness or increase breakthrough bleeding.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + St. John'S Wort— St. John's wort induces CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough b…
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Telaprevir— HCV protease inhibitor that may decrease plasma concentrations of estrogen and/or progestin.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Theophylline— COCs containing ethinyl estradiol may inhibit the metabolism of theophylline.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Tipranavir— HIV protease inhibitor (with ritonavir) may significantly decrease plasma concentrations of estrogen and/or progestin.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Tizanidine— COCs containing ethinyl estradiol may inhibit the metabolism of tizanidine.
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Topiramate— Topiramate induces CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough bleedi…
Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Voriconazole— COCs containing ethinyl estradiol may inhibit the metabolism of voriconazole.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Dasabuvir⛔Contraindicated

Do not co-administer (when used with ombitasvir/paritaprevir/ritonavir) due to potential for ALT elevations.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Ombitasvir/Paritaprevir/Ritonavir⛔Contraindicated

Do not co-administer due to potential for ALT elevations.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Acetaminophen🟡Moderate

Acetaminophen may increase plasma ethinyl estradiol levels.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Amprenavir🟡Moderate

HIV protease inhibitor (with ritonavir) may significantly decrease plasma concentrations of estrogen and/or progestin.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Aprepitant🟡Moderate

Induces CYP3A4, may decrease plasma concentrations of COCs and diminish effectiveness or increase breakthrough bleeding.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Ascorbic Acid🟡Moderate

Ascorbic acid may increase plasma ethinyl estradiol levels.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Atazanavir🟡Moderate

HIV protease inhibitor (with ritonavir) may significantly increase plasma concentrations of estrogen and/or progestin.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Atorvastatin🟡Moderate

Co-administration increases AUC values for ethinyl estradiol by approximately 20%.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Barbiturates🟡Moderate

Barbiturates induce CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough bleeding.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Boceprevir🟡Moderate

HCV protease inhibitor that may decrease plasma concentrations of estrogen and/or progestin.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Bosentan🟡Moderate

Bosentan induces CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough bleeding.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Carbamazepine🟡Moderate

Carbamazepine induces CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough bleeding.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Colesevelam🟡Moderate

Bile acid sequestrant significantly decreases AUC of ethinyl estradiol; effect reduced when given 4 hours apart.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Cyclosporine🟡Moderate

COCs containing ethinyl estradiol may inhibit the metabolism of cyclosporine.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Darunavir🟡Moderate

HIV protease inhibitor (with ritonavir) may significantly decrease plasma concentrations of estrogen and/or progestin.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Efavirenz🟡Moderate

Non-nucleoside reverse transcriptase inhibitor that may decrease plasma concentrations of estrogen and/or progestin.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Etravirine🟡Moderate

Non-nucleoside reverse transcriptase inhibitor may significantly increase plasma concentrations of estrogen and/or progestin.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Felbamate🟡Moderate

Felbamate induces CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough bleeding.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Fluconazole🟡Moderate

CYP3A4 inhibitor may increase plasma hormone concentrations.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Fosamprenavir🟡Moderate

HIV protease inhibitor (with ritonavir) may significantly decrease plasma concentrations of estrogen and/or progestin.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Grapefruit Juice🟡Moderate

CYP3A4 inhibitor may increase plasma hormone concentrations.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Griseofulvin🟡Moderate

Griseofulvin induces CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough bleeding.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Indinavir🟡Moderate

HIV protease inhibitor may significantly increase plasma concentrations of estrogen and/or progestin.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Itraconazole🟡Moderate

CYP3A4 inhibitor itraconazole may increase plasma hormone levels.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Ketoconazole🟡Moderate

CYP3A4 inhibitor ketoconazole may increase plasma hormone levels.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Lamotrigine🟡Moderate

COCs have been shown to significantly decrease plasma concentrations of lamotrigine.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Lopinavir🟡Moderate

HIV protease inhibitor (with ritonavir) may significantly decrease plasma concentrations of estrogen and/or progestin.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Lopinavir And Ritonavir🟡Moderate

HIV protease inhibitor combination that may decrease plasma concentrations of estrogen and/or progestin.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Nelfinavir🟡Moderate

HIV protease inhibitor may significantly decrease plasma concentrations of estrogen and/or progestin.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Nevirapine🟡Moderate

Non-nucleoside reverse transcriptase inhibitor may significantly decrease plasma concentrations of estrogen and/or progestin.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Oxcarbazepine🟡Moderate

Oxcarbazepine induces CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough bleeding.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Phenytoin🟡Moderate

Phenytoin induces CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough bleeding.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Prednisolone🟡Moderate

COCs containing ethinyl estradiol may inhibit the metabolism of prednisolone.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Rifabutin🟡Moderate

Induces CYP3A4, may decrease plasma concentrations of COCs and diminish effectiveness or increase breakthrough bleeding.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Rifampin🟡Moderate

Rifampin induces CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough bleeding.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Ritonavir🟡Moderate

HIV protease inhibitor may significantly decrease plasma concentrations of estrogen and/or progestin.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Rosuvastatin🟡Moderate

Increases AUC values for ethinyl estradiol by approximately 20-25%.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Rufinamide🟡Moderate

Induces CYP3A4, may decrease plasma concentrations of COCs and diminish effectiveness or increase breakthrough bleeding.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + St. John'S Wort🟡Moderate

St. John's wort induces CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough bleeding.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Telaprevir🟡Moderate

HCV protease inhibitor that may decrease plasma concentrations of estrogen and/or progestin.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Theophylline🟡Moderate

COCs containing ethinyl estradiol may inhibit the metabolism of theophylline.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Tipranavir🟡Moderate

HIV protease inhibitor (with ritonavir) may significantly decrease plasma concentrations of estrogen and/or progestin.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Tizanidine🟡Moderate

COCs containing ethinyl estradiol may inhibit the metabolism of tizanidine.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Topiramate🟡Moderate

Topiramate induces CYP3A4 enzymes, potentially decreasing contraceptive effectiveness and increasing breakthrough bleeding.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Voriconazole🟡Moderate

COCs containing ethinyl estradiol may inhibit the metabolism of voriconazole.

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Ombitasvirℹ️Unknown

7.3 Concomitant Use with HCV Combination Therapy – Liver Enzyme Elevation Do not co-administer Nexesta Fe with HCV drug combinations containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, due to potential for ALT elevations [see Warnings and Precautions (5.3) ].

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Paritaprevirℹ️Unknown

Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate + Temazepamℹ️Unknown

COCs have been shown to decrease plasma concentrations of acetaminophen, clofibric acid, morphine, salicylic acid, temazepam and lamotrigine.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.