Urea has 7 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Tobramycin, Tobramycin Inhalation Solution, Amikacin. Patients taking Urea should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 7
- Contraindicated
- 2
- Major
- 2
- Moderate
- 3
Contraindicated (2)
- Urea + Tobramycin— Concomitant administration not recommended due to possible enhancement of aminoglycoside toxicity by altering serum and …
- Urea + Tobramycin Inhalation Solution— Should not be administered concomitantly; diuretics can enhance aminoglycoside toxicity by altering antibiotic concentra…
Major (2)
- Urea + Amikacin— Can enhance aminoglycoside toxicity by altering serum and tissue concentrations. Avoid concomitant use.
- Urea + Tobramycin Solution— Concomitant administration can enhance aminoglycoside toxicity by altering aminoglycoside concentrations in serum and ti…
Moderate (3)
- Urea + Lithium— Can lower serum lithium concentrations by increasing urinary lithium excretion.
- Urea + Lithium Carbonate— Lowers serum lithium concentrations by increasing urinary lithium excretion; monitor lithium levels.
- Urea + Lithium Citrate— Can lower serum lithium concentrations by increasing urinary lithium excretion. Recommend frequent monitoring and dosage…