Vancomycin has 17 known drug interactions based on U.S. FDA drug labeling data. Of these, 4 are contraindicated combinations that should be avoided entirely. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Ceftriaxone, Ceftriaxone Sodium, Cidofovir. Patients taking Vancomycin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 17
- Contraindicated
- 4
- Major
- 5
- Moderate
- 6
Contraindicated (4)
- Vancomycin + Ceftriaxone— Physically incompatible with ceftriaxone in admixtures. Cannot be mixed in the same IV line.
- Vancomycin + Ceftriaxone Sodium— Physically incompatible with ceftriaxone in admixtures. Must not be mixed in the same intravenous administration line.
- Vancomycin + Cidofovir— Nephrotoxic agents Concomitant administration of cidofovir injection and agents with nephrotoxic potential [e.g., intrav…
- Vancomycin + Cidofovir Anhydrous— Nephrotoxic Agents Concomitant administration of cidofovir injection and agents with nephrotoxic potential [e.g., intrav…
Major (5)
- Vancomycin + Gentamicin Sulfate— Concurrent and/or sequential use should be avoided due to potential neurotoxicity and nephrotoxicity.
- Vancomycin + Pentamidine Isethionate— Concomitant or sequential use may have additive nephrotoxic effects; should be closely monitored and avoided if possible…
- Vancomycin + Piperacillin And Tazobactam— Co-administration increases incidence of acute kidney injury compared to vancomycin alone. Monitor kidney function in pa…
- Vancomycin + Rocuronium— May enhance neuromuscular blocking action of rocuronium, prolonging neuromuscular block.
- Vancomycin + Rocuronium Bromide— May enhance neuromuscular blocking action of rocuronium bromide, causing prolongation of neuromuscular block.
Moderate (6)
- Vancomycin + Cyclosporine— May potentiate renal dysfunction when used concomitantly with cyclosporine. Close monitoring of renal function required.
- Vancomycin + Metformin Hydrochloride— Cationic drug eliminated by renal tubular secretion with potential for interaction with metformin by competing for commo…
- Vancomycin + Piperacillin— ( 2.1 , 7.1 ) Piperacillin/Tazobactam : Increased incidence of acute kidney injury in patients receiving concomitant pip…
- Vancomycin + Topical Local Anesthetics— Concomitant administration has been associated with erythema and histamine-like flushing.
- Vancomycin + Trospium Chloride— May increase serum concentration of trospium and/or vancomycin due to competition for renal tubular secretion. Careful p…
- Vancomycin + Vancomycin Hydrochloride— Drug Interactions Concomitant administration of vancomycin and anesthetic agents has been associated with erythema and h…