Trihexyphenidyl Hydrochloride has 5 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Alcohol, Barbiturates, Cannabinoids. Patients taking Trihexyphenidyl Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 5
- Moderate
- 5
Moderate (5)
- Trihexyphenidyl Hydrochloride + Alcohol— Concurrent use may cause increased sedative effects and additive CNS depression with trihexyphenidyl.
- Trihexyphenidyl Hydrochloride + Barbiturates— Additive effects with trihexyphenidyl; abuse potential exists with concurrent use.
- Trihexyphenidyl Hydrochloride + Cannabinoids— Additive effects with trihexyphenidyl; abuse potential exists with concurrent use.
- Trihexyphenidyl Hydrochloride + Levodopa— Concomitant administration may increase drug-induced involuntary movements; dose of either drug may need reduction.
- Trihexyphenidyl Hydrochloride + Monoamine Oxidase Inhibitors (Maois)— May intensify anticholinergic effects of trihexyphenidyl due to secondary anticholinergic activities.