Vincristine has 12 known drug interactions based on U.S. FDA drug labeling data. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Aprepitant, Fosaprepitant, Fosaprepitant Dimeglumine. Patients taking Vincristine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 12
- Major
- 6
- Moderate
- 6
Major (6)
- Vincristine + Aprepitant— Increased chemotherapeutic agent exposure may increase risk of adverse reactions. Monitor for chemotherapy-related adver…
- Vincristine + Fosaprepitant— Increased exposure of chemotherapeutic agent may increase risk of adverse reactions. Monitor for chemotherapeutic-relate…
- Vincristine + Fosaprepitant Dimeglumine— Increased exposure of chemotherapeutic agent may increase risk of adverse reactions. Monitor for chemotherapeutic-relate…
- Vincristine + Ganciclovir Sodium— Associated with myelosuppression or nephrotoxicity; coadministration should be considered only if potential benefits out…
- Vincristine + Valganciclovir— Associated with myelosuppression or nephrotoxicity. Coadministration should be considered only if potential benefits out…
- Vincristine + Valganciclovir Hydrochloride— Co-administration with valganciclovir should be considered only if potential benefits outweigh risks due to potential fo…
Moderate (6)
- Vincristine + Gadobenate Dimeglumine— MultiHance may compete for MOAT transporter and prolong systemic exposure of vincristine.
- Vincristine + Ganciclovir— Associated with myelosuppression or nephrotoxicity. Coadministration considered only if benefits outweigh risks.
- Vincristine + Netupitant And Palonosetron— Chemotherapy agent metabolized by CYP3A4; systemic exposure can increase with AKYNZEO; caution and monitoring advised.
- Vincristine + Thalidomide— Vincristine causes peripheral neuropathy and concomitant use with thalidomide can cause additive effect; should be used …
- Vincristine + Vasopressin— Suspected of causing SIADH; may increase pressor and antidiuretic effects of vasopressin. Hemodynamic monitoring recomme…
- Vincristine + Vasopressin In 0.9% Sodium Chloride— May cause SIADH, increasing pressor and antidiuretic effects of vasopressin. Hemodynamic monitoring recommended; adjust …