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Vincristine Sulfate

Also known as: Vincristine Sulfate

Route: Intravenous

Check Vincristine Sulfate Interactions →

4 interactions on record⛔ Black Box Warning

Vincristine Sulfate has 4 known drug interactions based on U.S. FDA drug labeling data. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Fluconazole, Itraconazole, Phenytoin. Patients taking Vincristine Sulfate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 4
Major: 4

Major (4)

Vincristine Sulfate + Fluconazole— CYP3A inhibitor that causes earlier onset and/or increased severity of neuromuscular side effects. Moderate CYP3A inhibi…
Vincristine Sulfate + Itraconazole— CYP3A inhibitor that causes earlier onset and/or increased severity of neuromuscular side effects when used with vincris…
Vincristine Sulfate + Phenytoin— Simultaneous administration may reduce blood levels of phenytoin and increase seizure activity. Interaction may result f…
Vincristine Sulfate + St. John'S Wort— Strong CYP3A inducer that should be avoided during concurrent use with vincristine sulfate.

Vincristine Sulfate + Fluconazole⚠️Major

CYP3A inhibitor that causes earlier onset and/or increased severity of neuromuscular side effects. Moderate CYP3A inhibitor requiring frequent monitoring if used concurrently.

Vincristine Sulfate + Itraconazole⚠️Major

CYP3A inhibitor that causes earlier onset and/or increased severity of neuromuscular side effects when used with vincristine sulfate. Concomitant use should be avoided.

Vincristine Sulfate + Phenytoin⚠️Major

Simultaneous administration may reduce blood levels of phenytoin and increase seizure activity. Interaction may result from reduced absorption and increased metabolism/elimination of phenytoin.

Vincristine Sulfate + St. John'S Wort⚠️Major

Strong CYP3A inducer that should be avoided during concurrent use with vincristine sulfate.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.