Vitamin A has 7 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acitretin, Palovarotene, Tretinoin. Patients taking Vitamin A should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 7
- Contraindicated
- 3
- Major
- 1
- Moderate
- 3
Contraindicated (3)
- Vitamin A + Acitretin— Concomitant administration of vitamin A with acitretin must be avoided due to risk of hypervitaminosis A.
- Vitamin A + Palovarotene— May cause additive effects. Concomitant administration of vitamin A doses higher than RDA and other oral retinoids must …
- Vitamin A + Tretinoin— Concomitant use may lead to vitamin A related adverse reactions. Avoid concomitant use.
Major (1)
- Vitamin A + Isotretinoin— Additive toxic effects due to relationship of isotretinoin to vitamin A. Patients should avoid vitamin supplements conta…
Moderate (3)
- Vitamin A + Calcium Chloride— Increases risk of hypercalcemia when used concomitantly. Increase frequency of calcium concentration monitoring.
- Vitamin A + Calcium Chloride Dihydrate— Increases risk of hypercalcemia. Increase frequency of calcium concentration monitoring.
- Vitamin A + Calcium Gluconate— Concurrent administration may cause hypercalcemia. Monitor plasma calcium concentrations.