Vitamin D has 12 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Burosumab, Calcitriol, Calcitriol Capsules 0.25 Mcg. Patients taking Vitamin D should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 12
- Contraindicated
- 3
- Major
- 2
- Moderate
- 7
Contraindicated (3)
- Vitamin D + Burosumab— Concomitant use increases phosphate concentrations greater than expected, potentially resulting in hyperphosphatemia and…
- Vitamin D + Calcitriol— Pharmacological doses of vitamin D and derivatives should be withheld during calcitriol treatment to avoid additive effe…
- Vitamin D + Calcitriol Capsules 0.25 Mcg— Pharmacological doses of vitamin D and derivatives should be withheld during calcitriol treatment to avoid additive effe…
Major (2)
- Vitamin D + Paricalcitol— Concomitant administration of high doses may increase risk of hypercalcemia. Monitor calcium frequently and adjust paric…
- Vitamin D + Sodium Chloride, Sodium Lactate, Potassium Chloride, Calcium Chloride And Dextrose Monohydrate— Avoid concomitant use due to increased risk of hypercalcemia. If unavoidable, closely monitor serum calcium concentratio…
Moderate (7)
- Vitamin D + Calcium Chloride— Increases risk of hypercalcemia when used concomitantly. Increase frequency of calcium concentration monitoring.
- Vitamin D + Calcium Chloride Dihydrate— Increases risk of hypercalcemia. Increase frequency of calcium concentration monitoring.
- Vitamin D + Calcium Gluconate— Concurrent administration may cause hypercalcemia. Monitor plasma calcium concentrations.
- Vitamin D + Danazol— Danazol can increase the calcemic response to synthetic vitamin D analogs in primary hypoparathyroidism.
- Vitamin D + Doxercalciferol— Concomitant administration of other vitamin D compounds may increase the risk of hypercalcemia. Monitor serum calcium co…
- Vitamin D + Sodium Chloride, Calcium Chloride, And Potassium Chloride— Concomitant use increases risk of hypercalcemia. Avoid use; if unavoidable, closely monitor serum calcium concentrations…
- Vitamin D + Sodium Phosphate, Dibasic, Anhydrous, Potassium Phosphate, Monobasic, And Sodium Phosphate, Monobasic, Monohydrate— May antagonize the effects of phosphates in treatment of hypercalcemia.