Levetiracetam has 16 known drug interactions based on U.S. FDA drug labeling data. Patients taking Levetiracetam should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 16
- Minor
- 15
Minor (15)
- Levetiracetam + Brivaracetam— Brivaracetam provided no added therapeutic benefit when co-administered with levetiracetam.
- Levetiracetam + Brivaracetam Injection— Brivaracetam provided no added therapeutic benefit when co-administered with levetiracetam.
- Levetiracetam + Carbamazepine— Levetiracetam does not influence carbamazepine plasma concentration. Carbamazepine as an enzyme-inducing AED increased l…
- Levetiracetam + Digoxin— Levetiracetam did not influence digoxin pharmacokinetics or pharmacodynamics; digoxin did not influence levetiracetam ph…
- Levetiracetam + Gabapentin— Levetiracetam does not influence gabapentin plasma concentration and gabapentin does not influence levetiracetam pharmac…
- Levetiracetam + Lacosamide— Steady-state plasma concentrations of levetiracetam were not affected by concomitant lacosamide at any dose in clinical …
- Levetiracetam + Lamotrigine— Levetiracetam had no effect on lamotrigine plasma concentrations and lamotrigine did not influence levetiracetam pharmac…
- Levetiracetam + Oral Contraceptives— Levetiracetam did not influence pharmacokinetics of oral contraceptive containing ethinyl estradiol and levonorgestrel o…
- Levetiracetam + Phenobarbital— Levetiracetam does not influence phenobarbital plasma concentration and phenobarbital does not influence levetiracetam p…
- Levetiracetam + Phenytoin— Levetiracetam had no effect on phenytoin pharmacokinetics, and phenytoin did not affect levetiracetam pharmacokinetics.
- Levetiracetam + Primidone— Levetiracetam does not influence primidone plasma concentration and primidone does not influence levetiracetam pharmacok…
- Levetiracetam + Probenecid— Potential interaction assessed in clinical pharmacokinetic studies; no significant interaction reported.
- Levetiracetam + Topiramate— Levetiracetam had no effect on topiramate plasma concentrations in pediatric patients.
- Levetiracetam + Valproate— Levetiracetam did not alter valproate pharmacokinetics, and valproate did not modify levetiracetam absorption, clearance…
- Levetiracetam + Warfarin— Levetiracetam did not influence R and S warfarin pharmacokinetics or prothrombin time.