Crizotinib has 9 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Levoketoconazole, Lomitapide Mesylate, Calcium Channel Blockers. Patients taking Crizotinib should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 9
- Contraindicated
- 2
- Major
- 5
- Moderate
- 2
Contraindicated (2)
- Crizotinib + Levoketoconazole— Concomitant use is contraindicated due to increased risk of QT prolongation and torsades de pointes.
- Crizotinib + Lomitapide Mesylate— Concomitant use of moderate CYP3A4 inhibitors (such as amprenavir, aprepitant, atazanavir, ciprofloxacin, crizotinib, da…
Major (5)
- Crizotinib + Calcium Channel Blockers— Non-dihydropyridine calcium channel blockers cause bradycardia and should be avoided with crizotinib, which can also cau…
- Crizotinib + Clonidine— Clonidine causes bradycardia and should be avoided with crizotinib, which can also cause bradycardia.
- Crizotinib + Digoxin— Digoxin causes bradycardia and should be avoided with crizotinib, which can also cause bradycardia.
- Crizotinib + Itraconazole— Axitinib Bosutinib Cabazitaxel Cabozantinib Ceritinib Cobimetinib Crizotinib Dabrafenib Dasatinib Docetaxel Ibrutinib La…
- Crizotinib + Nonselective Beta-Adrenergic Antagonists— Beta-blockers cause bradycardia and should be avoided with crizotinib, which can also cause bradycardia.
Moderate (2)
- Crizotinib + Grapefruit Juice— Grapefruit juice may increase plasma concentrations of crizotinib, increasing risk of adverse reactions. Avoid concomita…
- Crizotinib + Grapefruit Products— Grapefruit may increase plasma concentrations of crizotinib, increasing risk of adverse reactions. Avoid concomitant use…