Atracurium has 7 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Magnesium Sulfate Heptahydrate, Magnesium Sulfate In Dextrose, Desflurane. Patients taking Atracurium should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 7
- Major
- 2
- Moderate
- 3
- Minor
- 2
Major (2)
- Atracurium + Magnesium Sulfate Heptahydrate— Potentiation and prolongation of neuromuscular blockade is possible with concomitant use. Monitor respiration and depth …
- Atracurium + Magnesium Sulfate In Dextrose— Potentiation and prolongation of neuromuscular blockade is possible. Magnesium suppresses peripheral neuromuscular funct…
Moderate (3)
- Atracurium + Desflurane— Desflurane reduces ED95 of atracurium by approximately 50%. Dose adjustment may be needed during maintenance anesthesia.
- Atracurium + Isoflurane— Isoflurane potentiates the muscle relaxant effect of atracurium, reducing required ED95 by approximately 25-40%. Dose ad…
- Atracurium + Sevoflurane— Sevoflurane increases both the intensity and duration of neuromuscular blockade induced by atracurium. Dosage adjustment…
Minor (2)
- Atracurium + Ondansetron— Ondansetron does not alter the degree of neuromuscular blockade produced by atracurium.
- Atracurium + Ondansetron Hydrochloride— Ondansetron does not alter the degree of neuromuscular blockade produced by atracurium.