Glucarpidase + LeucovorinModerate
GLUCARPIDASE can decrease leucovorin concentration, which may decrease the effect of leucovorin rescue unless leucovorin is dosed as recommended.
Source: NLP:glucarpidase
Glucarpidase Interactions
Brand names: Voraxaze
Carboxypeptidase
Route: Intravenous
Contraindications
4 CONTRAINDICATIONS None. None.
Pregnancy & Breastfeeding
8.1 Pregnancy Risk Summary There are no available data on VORAXAZE use in pregnant women or animal reproduction studies to evaluate for a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes. VORAXAZE is administered in combination with methotrexate, which can cause embryo-fetal harm. Refer to methotrexate prescribing information for additional information. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively.
2 interactions on record
Glucarpidase can decrease leucovorin concentrations, reducing the effect of leucovorin rescue. Administer at least 2 hours before or after glucarpidase dose.
Source: NLP:leucovorin calcium