Esomeprazole Sodium has 19 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Rilpivirine, Atazanavir, Clopidogrel. Patients taking Esomeprazole Sodium should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 19
- Contraindicated
- 1
- Major
- 6
- Moderate
- 3
Contraindicated (1)
- Esomeprazole Sodium + Rilpivirine— Concomitant use with esomeprazole sodium for injection is contraindicated due to decreased antiretroviral exposure that …
Major (6)
- Esomeprazole Sodium + Atazanavir— Decreased exposure when used concomitantly with esomeprazole may reduce antiviral effect and promote the development of …
- Esomeprazole Sodium + Clopidogrel— Concomitant use of esomeprazole 40 mg resulted in reduced plasma concentrations of the active metabolite and a reduction…
- Esomeprazole Sodium + Methotrexate— Concomitant use may elevate and prolong serum concentrations of methotrexate and its metabolite hydroxymethotrexate, pos…
- Esomeprazole Sodium + Nelfinavir— Decreased exposure of some antiretroviral drugs (e.g., rilpivirine atazanavir, and nelfinavir) when used concomitantly w…
- Esomeprazole Sodium + Saquinavir— Increased exposure when used concomitantly with esomeprazole may increase toxicity; monitor for potential saquinavir-rel…
- Esomeprazole Sodium + Warfarin— Increased INR and prothrombin time may lead to abnormal bleeding and even death; monitor INR and adjust warfarin dose to…
Moderate (3)
- Esomeprazole Sodium + Cilostazol— CYP2C19 substrate that may have altered exposure when used concomitantly with esomeprazole.
- Esomeprazole Sodium + Citalopram— CYP2C19 substrate that may have altered exposure when used concomitantly with esomeprazole.
- Esomeprazole Sodium + Diazepam— CYP2C19 substrate that may have altered exposure when used concomitantly with esomeprazole.