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Pantoprazole Sodium Granules

Also known as: Pantoprazole Sodium Delayed-Release Delayed Release

Route: Oral

Check Pantoprazole Sodium Granules Interactions →

13 interactions on record

Pantoprazole Sodium Granules has 13 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Rilpivirine, Atazanavir, Methotrexate. Patients taking Pantoprazole Sodium Granules should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 13
Contraindicated: 1
Major: 5
Moderate: 4

Contraindicated (1)

Pantoprazole Sodium Granules + Rilpivirine— Concomitant use with pantoprazole is contraindicated due to decreased exposure reducing antiviral effect and promoting d…

Major (5)

Pantoprazole Sodium Granules + Atazanavir— Decreased exposure of atazanavir when used concomitantly with pantoprazole may reduce antiviral effect and promote devel…
Pantoprazole Sodium Granules + Methotrexate— Concomitant use may elevate and prolong serum concentrations of methotrexate and hydroxymethotrexate, possibly leading t…
Pantoprazole Sodium Granules + Nelfinavir— Decreased exposure of some antiretroviral drugs (e.g., rilpivirine atazanavir, and nelfinavir) when used concomitantly w…
Pantoprazole Sodium Granules + Saquinavir— Increased exposure of saquinavir when used concomitantly with pantoprazole may increase toxicity of the antiretroviral d…
Pantoprazole Sodium Granules + Warfarin— Increased INR and prothrombin time may occur, potentially leading to abnormal bleeding and death. Monitor INR and dose a…

Moderate (4)

Pantoprazole Sodium Granules + Dasatinib— Pantoprazole reduces gastric pH which may decrease absorption of dasatinib.
Pantoprazole Sodium Granules + Erlotinib— Pantoprazole reduces gastric pH which may decrease absorption of erlotinib.
Pantoprazole Sodium Granules + Iron Salts— Pantoprazole reduces gastric pH which may decrease absorption of iron salts.
Pantoprazole Sodium Granules + Nilotinib— Pantoprazole reduces gastric pH which may decrease absorption of nilotinib.

Pantoprazole Sodium Granules + Rilpivirine⛔Contraindicated

Concomitant use with pantoprazole is contraindicated due to decreased exposure reducing antiviral effect and promoting drug resistance.

Pantoprazole Sodium Granules + Atazanavir⚠️Major

Decreased exposure of atazanavir when used concomitantly with pantoprazole may reduce antiviral effect and promote development of drug resistance.

Pantoprazole Sodium Granules + Methotrexate⚠️Major

Concomitant use may elevate and prolong serum concentrations of methotrexate and hydroxymethotrexate, possibly leading to toxicities, especially at high doses.

Pantoprazole Sodium Granules + Nelfinavir⚠️Major

Decreased exposure of some antiretroviral drugs (e.g., rilpivirine atazanavir, and nelfinavir) when used concomitantly with pantoprazole may reduce antiviral effect and promote the development of drug resistance. Nelfinavir: Avoid concomitant use with pantoprazole. See prescribing information for nelfinavir.

Pantoprazole Sodium Granules + Saquinavir⚠️Major

Increased exposure of saquinavir when used concomitantly with pantoprazole may increase toxicity of the antiretroviral drug.

Pantoprazole Sodium Granules + Warfarin⚠️Major

Increased INR and prothrombin time may occur, potentially leading to abnormal bleeding and death. Monitor INR and dose adjustment may be needed.

Pantoprazole Sodium Granules + Dasatinib🟡Moderate

Pantoprazole reduces gastric pH which may decrease absorption of dasatinib.

Pantoprazole Sodium Granules + Erlotinib🟡Moderate

Pantoprazole reduces gastric pH which may decrease absorption of erlotinib.

Pantoprazole Sodium Granules + Iron Salts🟡Moderate

Pantoprazole reduces gastric pH which may decrease absorption of iron salts.

Pantoprazole Sodium Granules + Nilotinib🟡Moderate

Pantoprazole reduces gastric pH which may decrease absorption of nilotinib.

Pantoprazole Sodium Granules + Itraconazoleℹ️Unknown

Drugs Dependent on Gastric pH for Absorption (e.g., iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole/itraconazole) Clinical Impact: Pantoprazole can reduce the absorption of other drugs due to its effect on reducing intragastric acidity.

Pantoprazole Sodium Granules + Ketoconazoleℹ️Unknown

Pantoprazole Sodium Granules + Pantoprazoleℹ️Unknown

7 DRUG INTERACTIONS Table 4 includes drugs with clinically important drug interactions and interaction with diagnostics when administered concomitantly with pantoprazole and instructions for preventing or managing them. Table 4: Clinically Relevant Interactions Affecting Drugs Co-Administered with Pantoprazole and Interactions with Diagnostics Antiretrovirals Clinical Impact: The effect of PPIs on antiretroviral drugs is variable. Decreased exposure of some antiretroviral drugs (e.g., rilpivirine atazanavir, and nelfinavir) when used concomitantly with pantoprazole may reduce antiviral effect and promote the development of drug resistance.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.