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Aripiprazole Orally Disintegrating

Also known as: Aripiprazole

Atypical Antipsychotic

Route: Oral

Check Aripiprazole Orally Disintegrating Interactions →

10 interactions on record⛔ Black Box Warning

Aripiprazole Orally Disintegrating has 10 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Carbamazepine, Clarithromycin, Fluoxetine. Patients taking Aripiprazole Orally Disintegrating should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 10
Moderate: 8

Moderate (8)

Aripiprazole Orally Disintegrating + Carbamazepine— Strong CYP3A4 inducer that decreases aripiprazole exposure. Consider increasing aripiprazole dosage when used concomitan…
Aripiprazole Orally Disintegrating + Clarithromycin— Strong CYP3A4 inhibitor that increases aripiprazole exposure. Reduce aripiprazole dosage when used concomitantly.
Aripiprazole Orally Disintegrating + Fluoxetine— Strong CYP2D6 inhibitor that increases aripiprazole exposure. Reduce aripiprazole dosage when used concomitantly.
Aripiprazole Orally Disintegrating + Itraconazole— Strong CYP3A4 inhibitor that increases aripiprazole exposure. Reduce aripiprazole dosage when used concomitantly.
Aripiprazole Orally Disintegrating + Lorazepam— Benzodiazepine that increases sedation intensity and orthostatic hypotension when combined with aripiprazole. Monitor se…
Aripiprazole Orally Disintegrating + Paroxetine— Strong CYP2D6 inhibitor that increases aripiprazole exposure. Reduce aripiprazole dosage when used concomitantly.
Aripiprazole Orally Disintegrating + Quinidine— Strong CYP2D6 inhibitor that increases aripiprazole exposure. Reduce aripiprazole dosage when used concomitantly.
Aripiprazole Orally Disintegrating + Rifampin— Strong CYP3A4 inducer that decreases aripiprazole exposure. Consider increasing aripiprazole dosage when used concomitan…

Aripiprazole Orally Disintegrating + Carbamazepine🟡Moderate

Strong CYP3A4 inducer that decreases aripiprazole exposure. Consider increasing aripiprazole dosage when used concomitantly.

Aripiprazole Orally Disintegrating + Clarithromycin🟡Moderate

Strong CYP3A4 inhibitor that increases aripiprazole exposure. Reduce aripiprazole dosage when used concomitantly.

Aripiprazole Orally Disintegrating + Fluoxetine🟡Moderate

Strong CYP2D6 inhibitor that increases aripiprazole exposure. Reduce aripiprazole dosage when used concomitantly.

Aripiprazole Orally Disintegrating + Itraconazole🟡Moderate

Strong CYP3A4 inhibitor that increases aripiprazole exposure. Reduce aripiprazole dosage when used concomitantly.

Aripiprazole Orally Disintegrating + Lorazepam🟡Moderate

Benzodiazepine that increases sedation intensity and orthostatic hypotension when combined with aripiprazole. Monitor sedation and blood pressure; adjust dose accordingly.

Aripiprazole Orally Disintegrating + Paroxetine🟡Moderate

Strong CYP2D6 inhibitor that increases aripiprazole exposure. Reduce aripiprazole dosage when used concomitantly.

Aripiprazole Orally Disintegrating + Quinidine🟡Moderate

Strong CYP2D6 inhibitor that increases aripiprazole exposure. Reduce aripiprazole dosage when used concomitantly.

Aripiprazole Orally Disintegrating + Rifampin🟡Moderate

Strong CYP3A4 inducer that decreases aripiprazole exposure. Consider increasing aripiprazole dosage when used concomitantly.

Aripiprazole Orally Disintegrating + Aripiprazoleℹ️Unknown

7 DRUG INTERACTIONS Dosage adjustment due to drug interactions ( 7.1 ): Factors Dosage Adjustments for Aripiprazole Known CYP2D6 Poor Metabolizers Administer half of usual dose Known CYP2D6 Poor Metabolizers and strong CYP3A4 inhibitors Administer a quarter of usual dose Strong CYP2D6 or CYP3A4 inhibitors Administer half of usual dose Strong CYP2D6 and CYP3A4 inhibitors Administer a quarter of usual dose Strong CYP3A4 inducers Double usual dose over 1 to 2 weeks 7.1 Drugs Having Clinically Important Interactions with Aripiprazole Table 22: Clinically Important Drug Interactions with Aripiprazole: Concomitant Drug Name or Drug Class Clinical Rationale Clinical Recommendation Strong CYP3A4 Inhibitors (e.g., itraconazole, clarithromycin) or strong CYP2D6 inhibitors (e.g., quinidine, fluoxetine, paroxetine) The concomitant use of aripiprazole with strong CYP3A4 or CYP2D6 inhibitors increased the exposure of aripiprazole compared to the use of aripiprazole alone [see Clinical Pharmacology (12.3) ] . With concomitant use of aripiprazole with a strong CYP3A4 inhibitor or CYP2D6 inhibitor, reduce the aripiprazole dosage [see Dosage and Administration (2.7) ] . Strong CYP3A4 Inducers (e.g., carbamazepine, rifampin) The concomitant use of aripiprazole and carbamazepine decreased the exposure of aripiprazole compared to the use of aripiprazole alone [see Clinical Pharmacology (12.3) ] .

Aripiprazole Orally Disintegrating + Omeprazoleℹ️Unknown

In addition, no dosage adjustment is necessary for substrates of CYP2D6 (e.g., dextromethorphan, fluoxetine, paroxetine, or venlafaxine), CYP2C9 (e.g., warfarin), CYP2C19 (e.g., omeprazole, warfarin, escitalopram), or CYP3A4 (e.g., dextromethorphan) when co-administered with aripiprazole.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.