Phentermine And Topiramate has 11 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Monoamine Oxidase Inhibitors (Maois), Valproic Acid, Alcohol. Patients taking Phentermine And Topiramate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 11
- Contraindicated
- 1
- Major
- 1
- Moderate
- 9
Contraindicated (1)
- Phentermine And Topiramate + Monoamine Oxidase Inhibitors (Maois)— Concomitant use increases risk of hypertensive crisis. Contraindicated during MAOI treatment and within 14 days of stopp…
Major (1)
- Phentermine And Topiramate + Valproic Acid— Concomitant administration with topiramate has been associated with hyperammonemia, a potentially serious condition.
Moderate (9)
- Phentermine And Topiramate + Alcohol— Concomitant use may potentiate CNS depression including dizziness and cognitive adverse reactions.
- Phentermine And Topiramate + Barbiturates— Concomitant use may potentiate CNS depression including dizziness and cognitive adverse reactions.
- Phentermine And Topiramate + Carbamazepine— Concomitant administration decreased topiramate plasma concentrations by 40% in epilepsy patients, reducing topiramate e…
- Phentermine And Topiramate + Hydrochlorothiazide— Concomitant administration increases topiramate Cmax by 27% and AUC by 29%. Requires potassium monitoring.
- Phentermine And Topiramate + Nitrazepam— Concomitant use may potentiate CNS depression including dizziness and cognitive adverse reactions.
- Phentermine And Topiramate + Norethindrone And Ethinyl Estradiol— Co-administration decreased ethinyl estradiol exposure by 16% and increased norethindrone exposure by 22%, potentially c…
- Phentermine And Topiramate + Phenytoin— Concomitant administration decreased topiramate plasma concentrations by 48% in epilepsy patients, reducing topiramate e…
- Phentermine And Topiramate + Potassium Supplements— Concurrent use may potentiate potassium-wasting action of diuretics. Requires potassium monitoring.
- Phentermine And Topiramate + Sleep Medications— Concomitant use may potentiate CNS depression including dizziness and cognitive adverse reactions.