Enzalutamide Interactions

Androgen Receptors enzalutamide ↓ doravirine Co-administration is contraindicated with enzalutamide.

Source: FDA drug label - doravirine

Androgen Receptors enzalutamide ↓ doravirine Co-administration is contraindicated with enzalutamide.

Source: FDA drug label - doravirine, lamivudine, and tenofovir disoproxil fumarate

Concomitant Drug Class: Drug Name Effect on Concentration of Temsavir and/or Concomitant Drug Clinical Comment Androgen receptor inhibitor: Enzalutamide ↓Temsavir Coadministration is contraindicated due to potential for loss of therapeutic effect to RUKOBIA [see Contraindications ( 4 )] .

Source: FDA drug label - fostemsavir tromethamine

Anticancer drugs apalutamide, enzalutamide ↓ nirmatrelvir/ritonavir Co-administration contraindicated due to potential loss of virologic response and possible resistance [see Contraindications (4) ].

Source: FDA drug label - nirmatrelvir and ritonavir

Avoid concomitant use of strong CYP3A inducers (e.g., phenytoin, rifampin, carbamazepine, enzalutamide, and St John's Wort) [see Clinical Pharmacology (12.3) ] .

Source: FDA drug label - palbociclib

(C) CYP2C8 Substrates: Gemfibrozil is a strong inhibitor of CYP2C8 and may increase exposure of drugs mainly metabolized by CYP2C8 (e.g., dabrafenib, enzalutamide, loperamide, montelukast, paclitaxel, pioglitazone, rosiglitazone). Enzalutamide: In healthy volunteers given a single 160 mg dose of enzalutamide after gemfibrozil 600 mg twice daily, the AUC of enzalutamide plus active metabolite (N-desmethyl enzalutamide) was increased by 2.2 fold and corresponding C max was decreased by 16%. Increased enzalutamide exposure may increase the risk of seizures.

Source: FDA drug label - gemfibrozil

7.2 Cytochrome P450 (CYP) 3A4 Inducers Co-administration of a strong CYP3A4 inducer with MACRILEN (e.g., carbamazepine, enzalutamide, mitotane, phenytoin, rifampin, St.

Source: FDA drug label - macimorelin acetate

Examples Carbamazepine, enzalutamide, mitotane, phenytoin, rifampin, St.

Source: FDA drug label - rydapt

HRR Gene-mutated mCRPC The effect of coadministration of P-gp inhibitors on talazoparib exposure when TALZENNA is taken with enzalutamide has not been studied.

Source: FDA drug label - talazoparib