Cytotoxic Agents has 7 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Allopurinol Sodium, Cisplatin, Tamoxifen Citrate. Patients taking Cytotoxic Agents should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 7
- Major
- 3
- Moderate
- 4
Major (3)
- Cytotoxic Agents + Allopurinol Sodium— Concomitant use increases bone marrow suppression in neoplastic disease patients (except leukemia). Monitor blood counts…
- Cytotoxic Agents + Cisplatin— Concomitant use of ototoxic drugs with cisplatin increases risk of hearing loss and ototoxicity.
- Cytotoxic Agents + Tamoxifen Citrate— Increased risk of thromboembolic events when used in combination with tamoxifen.
Moderate (4)
- Cytotoxic Agents + Busulfan— Busulfan-induced pulmonary toxicity may be additive to effects of other cytotoxic agents.
- Cytotoxic Agents + Dextrose Monohydrate— Certain cytotoxic drugs may increase risk of hyponatremia through SIADH. Monitor serum sodium concentrations closely dur…
- Cytotoxic Agents + Sodium Chloride, Calcium Chloride, And Potassium Chloride— Certain cytotoxic drugs may increase hyponatremia risk. Avoid use; if unavoidable, closely monitor serum sodium concentr…
- Cytotoxic Agents + Sodium Chloride, Sodium Lactate, Potassium Chloride, Calcium Chloride And Dextrose Monohydrate— Certain cytotoxic drugs cause SIADH and may increase hyponatremia risk. Avoid use and monitor serum sodium if concomitan…