Brimonidine Interactions

Brand names: Brimonidine

Route: Topical

Contraindications

4 CONTRAINDICATIONS Brimonidine topical gel is contraindicated in patients who have experienced a hypersensitivity reaction to any component. Reactions have included angioedema, urticarial, and contact dermatitis [ see Warnings and Precautions ( 5.6 ) and Adverse Reactions ( 6.1 , 6.2 ) ]. Known hypersensitivity to any component of brimonidine topical gel ( 4 )

Pregnancy & Breastfeeding

8.1 Pregnancy Pregnancy Category B. There are no adequate and well-controlled studies of brimonidine topical gel in pregnant women. In animal studies, brimonidine crossed the placenta and entered into the fetal circulation to a limited extent. Brimonidine topical gel should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Brimonidine tartrate was not teratogenic when given at oral doses up to 2.5 mg/kg/day in pregnant rats during gestation days 6 through 15 and 5 mg/kg/day in pregnant rabbits during gestation days 6 through 18.

8 interactions on record

Brimonidine + AlcoholModerate

Possibility of additive or potentiating CNS depressant effect with brimonidine.

Source: NLP:brimonidine

Brimonidine + Anti-ArrhythmicsModerate

Alpha-2 agonists may reduce blood pressure; caution advised when using anti-hypertensives concurrently.

Source: NLP:brimonidine

Brimonidine + BarbituratesModerate

Possibility of additive or potentiating CNS depressant effect with brimonidine.

Source: NLP:brimonidine

Brimonidine + Cardiac GlycosidesModerate

Alpha-2 agonists may reduce blood pressure; caution advised when using cardiac glycosides concurrently.

Source: NLP:brimonidine

Brimonidine + SedativesModerate

Possibility of additive or potentiating CNS depressant effect with brimonidine.

Source: NLP:brimonidine