Topical Steroids has 23 known drug interactions based on U.S. FDA drug labeling data. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Edetate Calcium Disodium, Phenylephrine Hci, Phenylephrine Hydrochloride. Patients taking Topical Steroids should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 23
- Major
- 5
- Moderate
- 17
Major (5)
- Topical Steroids + Edetate Calcium Disodium— Steroids enhance the renal toxicity of edetate calcium disodium in animals.
- Topical Steroids + Phenylephrine Hci— Increase the pressor effect of phenylephrine hydrochloride.
- Topical Steroids + Phenylephrine Hydrochloride— Increase the pressor effect of phenylephrine hydrochloride.
- Topical Steroids + Phenylephrine Hydrochloride Injection, Solution— Steroids increase pressor effect of phenylephrine hydrochloride.
- Topical Steroids + Promethazine, Phenylephrine, Codeine— Concomitant use may enhance the pressor response and increase the risk of hypertension.
Moderate (17)
- Topical Steroids + Aclidinium Bromide And Formoterol Fumarate— Concomitant treatment may potentiate hypokalemic effect of beta-adrenergic agonist formoterol. Use with caution.
- Topical Steroids + Arformoterol Tartrate— May potentiate hypokalemia or ECG changes. Use with caution.
- Topical Steroids + Formoterol Fumarate— May potentiate hypokalemic effect of formoterol. Use with caution.
- Topical Steroids + Formoterol Fumarate Dihydrate— May potentiate hypokalemic effect of formoterol. Use with caution.
- Topical Steroids + Glimepiride— May increase glucose-lowering effect of glimepiride, increasing susceptibility to hypoglycemia.
- Topical Steroids + Glycopyrrolate And Formoterol Fumarate— Concomitant use may potentiate hypokalemic effect of formoterol. Use with caution.
- Topical Steroids + Histamine— Lessen the skin test wheal and erythema responses elicited by histamine at the skin test site. Should be discontinued fo…
- Topical Steroids + Ipratropium Bromide Inhalation— Concomitant use documented in COPD treatment; no formal studies fully evaluating interaction effects with respect to saf…
- Topical Steroids + Levothyroxine Sodium— May decrease serum thyroxine-binding globulin concentration, resulting in initial transient increase in FT4 followed by …
- Topical Steroids + Liothyronine Sodium— May decrease serum thyroxine-binding globulin concentration, altering T3 serum transport. Closely monitor thyroid hormon…
- Topical Steroids + Methazolamide— Concomitant use may lead to hypokalemia development. Use with caution and monitor potassium levels.
- Topical Steroids + Methotrexate— May elevate and prolong serum methotrexate levels and increase toxicity; can be continued or reduced gradually in respon…
- Topical Steroids + Metoprolol Tartrate And Hydrochlorothiazide— Concomitant use of steroids with hydrochlorothiazide may cause hypokalemia, which can sensitize the heart to toxic effec…
- Topical Steroids + Olodaterol Respimat Inhalation Spray— May potentiate hypokalemic effect of olodaterol. Use with caution.
- Topical Steroids + Somatropin— Somatropin may alter clearance of sex steroids metabolized by CYP450 liver enzymes; careful monitoring is advised.
- Topical Steroids + Tesamorelin— GH may alter clearance of sex steroids metabolized by CYP450 liver enzymes; monitor for potential interactions.
- Topical Steroids + Tiotropium Bromide And Olodaterol— Steroids may potentiate hypokalemia or ECG changes when used with olodaterol. Use with caution.