Lomitapide has 3 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Itraconazole, Ezetimibe And Simvastatin, Simvastatin. Patients taking Lomitapide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 3
- Contraindicated
- 1
- Major
- 2
Contraindicated (1)
- Lomitapide + Itraconazole— Coadministration is contraindicated. Itraconazole increases plasma concentrations, potentially increasing pharmacologic …
Major (2)
- Lomitapide + Ezetimibe And Simvastatin— For patients with HoFH, do not exceed 10 mg/20 mg ezetimibe and simvastatin tablets daily; special restrictions apply fo…
- Lomitapide + Simvastatin— Approximately doubles simvastatin exposure and increases risk of myopathy and rhabdomyolysis.