Levothyroxine Sodium Anhydrous has 8 known drug interactions based on U.S. FDA drug labeling data. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amitriptyline, Digitalis Glycosides, Ketamine. Patients taking Levothyroxine Sodium Anhydrous should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 8
- Major
- 5
- Moderate
- 3
Major (5)
- Levothyroxine Sodium Anhydrous + Amitriptyline— Concurrent use may increase therapeutic and toxic effects of both drugs, including increased risk of cardiac arrhythmias…
- Levothyroxine Sodium Anhydrous + Digitalis Glycosides— Therapeutic effects of digitalis glycosides may be reduced by levothyroxine. Serum digitalis glycoside levels may decrea…
- Levothyroxine Sodium Anhydrous + Ketamine— Concurrent use may produce marked hypertension and tachycardia. Cautious administration to patients receiving thyroid ho…
- Levothyroxine Sodium Anhydrous + Maprotiline— Concurrent use may increase therapeutic and toxic effects of both drugs, including increased risk of cardiac arrhythmias…
- Levothyroxine Sodium Anhydrous + Oral Anticoagulants— Levothyroxine increases the response to oral anticoagulant therapy. Decrease in anticoagulant dose may be warranted with…
Moderate (3)
- Levothyroxine Sodium Anhydrous + Acidifying Agents— Addition of levothyroxine to antidiabetic therapy may result in increased antidiabetic agent requirements. Careful monit…
- Levothyroxine Sodium Anhydrous + Insulin Human— Addition of levothyroxine to insulin therapy may result in increased insulin requirements. Careful monitoring of diabeti…
- Levothyroxine Sodium Anhydrous + Sertraline— Administration of sertraline in patients stabilized on levothyroxine may result in increased levothyroxine requirements.