Concurrent use may increase therapeutic and toxic effects of both drugs, including increased risk of cardiac arrhythmias and CNS stimulation, with accelerated onset of tricyclic action.
Source: NLP:levothyroxine sodium anhydrous
Levothyroxine Sodium Anhydrous Interactions
Brand names: Levothyroxine Sodium
Route: Intravenous
FDA Black Box Warning
WARNING: NOT FOR TREATMENT OF OBESITY OR FOR WEIGHT LOSS Thyroid hormones, including Levothyroxine Sodium for Injection, should not be used for the treatment of obesity or for weight loss. ( 5.3 ) Larger doses may produce serious or even life threatening manifestations of toxicity. ( 6 ) WARNING: NOT FOR TREATMENT OF OBESITY OR FOR WEIGHT LOSS Thyroid hormones, including Levothyroxine Sodium for Injection, should not be used for the treatment of obesity or for weight loss. ( 5.3 ) Larger doses may produce serious or even life threatening manifestations of toxicity. ( 6 )
Contraindications
4 CONTRAINDICATIONS None. None. ( 4 )
Pregnancy & Breastfeeding
8.1 Pregnancy Pregnancy Category A – There are no reported cases of Levothyroxine Sodium for Injection used to treat myxedema coma in patients who were pregnant or lactating. Studies in pregnant women treated with oral levothyroxine to maintain a euthyroid state have not shown an increased risk of fetal abnormalities. Therefore, pregnant patients who develop myxedema should be treated with Levothyroxine Sodium for Injection as the risk of nontreatment is associated with a high probability of significant morbidity or mortality to the maternal patient and the fetus.
8 interactions on record
Therapeutic effects of digitalis glycosides may be reduced by levothyroxine. Serum digitalis glycoside levels may decrease when hypothyroid patient becomes euthyroid, necessitating dose increase.
Source: NLP:levothyroxine sodium anhydrous
Concurrent use may produce marked hypertension and tachycardia. Cautious administration to patients receiving thyroid hormone therapy is recommended.
Source: NLP:levothyroxine sodium anhydrous
Concurrent use may increase therapeutic and toxic effects of both drugs, including increased risk of cardiac arrhythmias and CNS stimulation, with accelerated onset of action.
Source: NLP:levothyroxine sodium anhydrous
Levothyroxine increases the response to oral anticoagulant therapy. Decrease in anticoagulant dose may be warranted with correction of hypothyroidism. Prothrombin time should be closely monitored.
Source: NLP:levothyroxine sodium anhydrous
Addition of levothyroxine to antidiabetic therapy may result in increased antidiabetic agent requirements. Careful monitoring of diabetic control is recommended.
Source: NLP:levothyroxine sodium anhydrous
Addition of levothyroxine to insulin therapy may result in increased insulin requirements. Careful monitoring of diabetic control is recommended.
Source: NLP:levothyroxine sodium anhydrous
Administration of sertraline in patients stabilized on levothyroxine may result in increased levothyroxine requirements.
Source: NLP:levothyroxine sodium anhydrous