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Does Levothyroxine Sodium Anhydrous Interact with Maprotiline?

Levothyroxine Sodium Anhydrous and Maprotiline have a major drug interaction according to U.S. FDA drug labeling data. Concurrent use may increase therapeutic and toxic effects of both drugs, including increased risk of cardiac arrhythmias and CNS stimulation, with accelerated onset of action. The mechanism involves increased receptor sensitivity to catecholamines. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Levothyroxine Sodium Anhydrous and Maprotiline occurs because increased receptor sensitivity to catecholamines. Clinically, this means concurrent use may increase therapeutic and toxic effects of both drugs, including increased risk of cardiac arrhythmias and cns stimulation, with accelerated onset of action. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Levothyroxine Sodium Anhydrous and your doctor is considering prescribing Maprotiline (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Levothyroxine Sodium Anhydrous(Levothyroxine Sodium)+💊 Maprotiline

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:levothyroxine sodium anhydrous

What this means in plain English

Concurrent use may increase therapeutic and toxic effects of both drugs, including increased risk of cardiac arrhythmias and CNS stimulation, with accelerated onset of action.

What the FDA label says

"Increased receptor sensitivity to catecholamines"

📖 Source: NLP:levothyroxine sodium anhydrous

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.