Bisoprolol Fumarate has 12 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Nonselective Beta-Adrenergic Antagonists, Clonidine, Digitalis Glycosides. Patients taking Bisoprolol Fumarate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 12
- Contraindicated
- 1
- Major
- 8
- Moderate
- 1
- Minor
- 1
Contraindicated (1)
- Bisoprolol Fumarate + Nonselective Beta-Adrenergic Antagonists— Bisoprolol fumarate should not be combined with other beta-blocking agents.
Major (8)
- Bisoprolol Fumarate + Clonidine— Bisoprolol fumarate should be discontinued several days before clonidine withdrawal to avoid excessive sympathetic rebou…
- Bisoprolol Fumarate + Digitalis Glycosides— Both slow AV conduction and decrease heart rate; concomitant use increases risk of bradycardia.
- Bisoprolol Fumarate + Diltiazem— Calcium antagonist that depresses myocardium and inhibits AV conduction; use with care when combined with bisoprolol fum…
- Bisoprolol Fumarate + Disopyramide— Antiarrhythmic agent that depresses myocardium and inhibits AV conduction; use with care when combined with bisoprolol f…
- Bisoprolol Fumarate + Epinephrine— Patients with history of severe anaphylactic reactions may be unresponsive to usual doses of epinephrine while taking be…
- Bisoprolol Fumarate + Guanethidine— Catecholamine-depleting drug that may produce excessive reduction of sympathetic activity when combined with bisoprolol …
- Bisoprolol Fumarate + Reserpine— Catecholamine-depleting drug that may produce excessive reduction of sympathetic activity when combined with bisoprolol …
- Bisoprolol Fumarate + Verapamil— Calcium antagonist that depresses myocardium and inhibits AV conduction; use with care when combined with bisoprolol fum…
Moderate (1)
- Bisoprolol Fumarate + Rifampin— Increases metabolic clearance of bisoprolol fumarate, resulting in shortened elimination half-life; initial dose modific…
Minor (1)
- Bisoprolol Fumarate + Warfarin— No effect of bisoprolol fumarate on prothrombin time in patients on stable doses of warfarin.