Albuterol Sulfate has 20 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Epinephrine, Nonselective Beta-Adrenergic Antagonists, Short-Acting Antacids. Patients taking Albuterol Sulfate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 20
- Contraindicated
- 3
- Major
- 7
- Moderate
- 10
Contraindicated (3)
- Albuterol Sulfate + Epinephrine— Should not be used concomitantly with albuterol inhalation solution.
- Albuterol Sulfate + Nonselective Beta-Adrenergic Antagonists— Beta-adrenergic blocking agents block pulmonary effects of albuterol and may produce severe bronchospasm in asthmatic pa…
- Albuterol Sulfate + Short-Acting Antacids— Should not be used concomitantly with Albuterol Sulfate Inhalation Aerosol due to risk of potentiating effects.
Major (7)
- Albuterol Sulfate + Anti-Arrhythmics— Patients receiving epinephrine with anti-arrhythmics should be observed carefully for development of cardiac arrhythmias…
- Albuterol Sulfate + Cardiac Glycosides— Patients receiving epinephrine with cardiac glycosides should be observed carefully for development of cardiac arrhythmi…
- Albuterol Sulfate + Diuretics— Patients receiving epinephrine with diuretics should be observed carefully for development of cardiac arrhythmias.
- Albuterol Sulfate + Ergot Alkaloids— Ergot alkaloids may reverse the pressor effects of epinephrine.
- Albuterol Sulfate + Monoamine Oxidase Inhibitors (Maois)— May potentiate cardiovascular effects of albuterol. Use with extreme caution or consider alternative therapy.
- Albuterol Sulfate + Phentolamine— Alpha-adrenergic blocking drugs antagonize the vasoconstricting and hypertensive effects of epinephrine.
- Albuterol Sulfate + Propranolol— Beta-adrenergic blocking drugs antagonize the cardiostimulating and bronchodilating effects of epinephrine.
Moderate (10)
- Albuterol Sulfate + Andthiazide— Non-potassium sparing diuretics can have ECG changes and hypokalemia acutely worsened by beta-agonists, especially at ex…
- Albuterol Sulfate + Chlorpheniramine— Chlorpheniramine potentiates the effects of epinephrine.
- Albuterol Sulfate + Digoxin— May decrease serum digoxin levels (16-22% reduction demonstrated). Monitor digoxin levels carefully during concomitant u…
- Albuterol Sulfate + Diphenhydramine— Diphenhydramine potentiates the effects of epinephrine.
- Albuterol Sulfate + Levothyroxine— Levothyroxine sodium potentiates the effects of epinephrine.
- Albuterol Sulfate + Levothyroxine Sodium— Effects of epinephrine may be potentiated by levothyroxine sodium.
- Albuterol Sulfate + Loop Diuretics— Non-potassium sparing diuretics can have ECG changes and hypokalemia acutely worsened by beta-agonists, especially at ex…
- Albuterol Sulfate + Nonpotassium-Sparing Diuretics— ECG changes and hypokalemia from nonpotassium-sparing diuretics can be acutely worsened by albuterol, especially at exce…
- Albuterol Sulfate + Potassium Supplements— ECG changes and hypokalemia from non-potassium-sparing diuretics can be worsened by beta-agonists. Use with caution, esp…
- Albuterol Sulfate + Tripelennamine— Tripelennamine potentiates the effects of epinephrine.