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Fentanyl Citrate

Also known as: Fentanyl Citrate

Route: Intramuscular, Intravenous

10 interactions on record⛔ Black Box Warning

Fentanyl Citrate has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alcohol, Nitrazepam, Carbamazepine. Patients taking Fentanyl Citrate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 10
Contraindicated: 2
Major: 8

Contraindicated (2)

Fentanyl Citrate + Alcohol— CNS depressant that increases risk of respiratory depression, profound sedation, coma, and death when combined with fent…
Fentanyl Citrate + Nitrazepam— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…

Major (8)

Fentanyl Citrate + Carbamazepine— CYP3A4 inducer that decreases fentanyl plasma concentration, resulting in decreased efficacy, withdrawal syndrome, and u…
Fentanyl Citrate + Diazepam— CNS depressant that with fentanyl can cause decreased pulmonary artery pressure, hypotension, respiratory depression, pr…
Fentanyl Citrate + Erythromycin— CYP3A4 inhibitor that increases fentanyl plasma concentration, resulting in increased or prolonged opioid effects, parti…
Fentanyl Citrate + Grapefruit Juice— CYP3A4 inhibitor that increases fentanyl plasma concentration, resulting in increased or prolonged opioid effects and re…
Fentanyl Citrate + Ketoconazole— Azole antifungal and CYP3A4 inhibitor that increases fentanyl plasma concentration, resulting in increased or prolonged …
Fentanyl Citrate + Phenytoin— CYP3A4 inducer that decreases fentanyl plasma concentration, resulting in decreased efficacy, withdrawal syndrome, and u…
Fentanyl Citrate + Rifampin— CYP3A4 inducer that decreases fentanyl plasma concentration, resulting in decreased efficacy, withdrawal syndrome, and u…
Fentanyl Citrate + Ritonavir— Protease inhibitor and CYP3A4 inhibitor that increases fentanyl plasma concentration, resulting in increased or prolonge…

Fentanyl Citrate + Alcohol⛔Contraindicated

CNS depressant that increases risk of respiratory depression, profound sedation, coma, and death when combined with fentanyl.

Fentanyl Citrate + Nitrazepam⛔Contraindicated

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Fentanyl Citrate + Carbamazepine⚠️Major

CYP3A4 inducer that decreases fentanyl plasma concentration, resulting in decreased efficacy, withdrawal syndrome, and upon discontinuation, potential serious respiratory depression.

Fentanyl Citrate + Diazepam⚠️Major

CNS depressant that with fentanyl can cause decreased pulmonary artery pressure, hypotension, respiratory depression, profound sedation, coma, and death.

Fentanyl Citrate + Erythromycin⚠️Major

CYP3A4 inhibitor that increases fentanyl plasma concentration, resulting in increased or prolonged opioid effects, particularly respiratory depression and sedation.

Fentanyl Citrate + Grapefruit Juice⚠️Major

CYP3A4 inhibitor that increases fentanyl plasma concentration, resulting in increased or prolonged opioid effects and respiratory depression.

Fentanyl Citrate + Ketoconazole⚠️Major

Azole antifungal and CYP3A4 inhibitor that increases fentanyl plasma concentration, resulting in increased or prolonged opioid effects and respiratory depression.

Fentanyl Citrate + Phenytoin⚠️Major

CYP3A4 inducer that decreases fentanyl plasma concentration, resulting in decreased efficacy, withdrawal syndrome, and upon discontinuation, potential serious respiratory depression.

Fentanyl Citrate + Rifampin⚠️Major

CYP3A4 inducer that decreases fentanyl plasma concentration, resulting in decreased efficacy, withdrawal syndrome, and upon discontinuation, potential serious respiratory depression.

Fentanyl Citrate + Ritonavir⚠️Major

Protease inhibitor and CYP3A4 inhibitor that increases fentanyl plasma concentration, resulting in increased or prolonged opioid effects and respiratory depression.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.