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Naproxen Sodium

Also known as: Naproxen Sodium

Nonsteroidal Anti-inflammatory DrugCyclooxygenase Inhibitors

Route: Oral

7 interactions on record⛔ Black Box Warning

Naproxen Sodium has 7 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetylsalicylic Acid, Selective Serotonin Reuptake Inhibitors (Ssri), Warfarin. Patients taking Naproxen Sodium should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 7
Major: 3
Moderate: 3

Major (3)

Naproxen Sodium + Acetylsalicylic Acid— Lower dose naproxen interferes with antiplatelet effect of low-dose aspirin; concomitant use increases GI adverse reacti…
Naproxen Sodium + Selective Serotonin Reuptake Inhibitors (Ssri)— Concomitant use potentiates bleeding risk more than NSAID alone due to serotonin reuptake interference.
Naproxen Sodium + Warfarin— Synergistic effect on bleeding with increased risk of serious bleeding compared to either drug alone.

Moderate (3)

Naproxen Sodium + Acidifying Agents— Concomitant use with naproxen increases bleeding risk. Monitor for signs of bleeding.
Naproxen Sodium + Furosemide— Diuretics Clinical Impact: Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natr…
Naproxen Sodium + Propranolol— NSAIDs may diminish the antihypertensive effect of beta-blockers including propranolol.

Naproxen Sodium + Acetylsalicylic Acid⚠️Major

Lower dose naproxen interferes with antiplatelet effect of low-dose aspirin; concomitant use increases GI adverse reactions and bleeding risk.

Naproxen Sodium + Selective Serotonin Reuptake Inhibitors (Ssri)⚠️Major

Concomitant use potentiates bleeding risk more than NSAID alone due to serotonin reuptake interference.

Naproxen Sodium + Warfarin⚠️Major

Synergistic effect on bleeding with increased risk of serious bleeding compared to either drug alone.

Naproxen Sodium + Acidifying Agents🟡Moderate

Concomitant use with naproxen increases bleeding risk. Monitor for signs of bleeding.

Naproxen Sodium + Furosemide🟡Moderate

Diuretics Clinical Impact: Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. In such high risk patients, monitor for signs of worsening renal function ( 7 ) Diuretics : NSAIDs can reduce natriuretic effect of furosemide and thiazide diuretics.

Naproxen Sodium + Propranolol🟡Moderate

NSAIDs may diminish the antihypertensive effect of beta-blockers including propranolol.

Naproxen Sodium + Acetazolamideℹ️Unknown

Intervention: Patients simultaneously receiving naproxen sodium and a hydantoin, sulphonamide or sulphonylurea should be observed for adjustment of dose if required.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.