Promethazine Hydrochloride has 9 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Epinephrine, Barbiturates, Mao Inhibitors. Patients taking Promethazine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 9
- Contraindicated
- 1
- Major
- 6
- Moderate
- 2
Contraindicated (1)
- Promethazine Hydrochloride + Epinephrine— Epinephrine should NOT be used to treat hypotension associated with promethazine overdose due to reversal of vasopressor…
Major (6)
- Promethazine Hydrochloride + Barbiturates— Promethazine increases sedative action; dose of barbiturates should be reduced by at least one-half.
- Promethazine Hydrochloride + Mao Inhibitors— Concomitant use with MAO inhibitors has been associated with increased incidence of extrapyramidal effects; this possibi…
- Promethazine Hydrochloride + Monoamine Oxidase Inhibitors (Maois)— Concomitant use with MAOIs and phenothiazines may result in increased incidence of extrapyramidal effects; possibility s…
- Promethazine Hydrochloride + Opioid Analgesics— Promethazine may increase, prolong, or intensify the sedative action; doses should be reduced by one-quarter to one-half…
- Promethazine Hydrochloride + Topical Local Anesthetics— Promethazine may increase, prolong, or intensify the sedative action of general anesthetics; avoid or use reduced dosage…
- Promethazine Hydrochloride + Tranquilizers— Promethazine may increase, prolong, or intensify the sedative action; avoid or use reduced dosage.
Moderate (2)
- Promethazine Hydrochloride + Alcohol— Promethazine may increase, prolong, or intensify the sedative action of alcohol; avoid or use reduced dosage.
- Promethazine Hydrochloride + Sedatives— Promethazine may increase, prolong, or intensify the sedative action of sedatives/hypnotics. Such agents should be avoid…