Tetracycline Hydrochloride has 15 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Methoxyflurane, Penicillin, Tetracycline. Patients taking Tetracycline Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 15
- Contraindicated
- 1
- Major
- 2
- Moderate
- 12
Contraindicated (1)
- Tetracycline Hydrochloride + Methoxyflurane— Concurrent use has been reported to result in fatal renal toxicity.
Major (2)
- Tetracycline Hydrochloride + Penicillin— Drug Interactions Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable t…
- Tetracycline Hydrochloride + Tetracycline— Drug Interactions Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable t…
Moderate (12)
- Tetracycline Hydrochloride + Antacids Containing Aluminum— Antacids containing aluminum impair absorption of tetracyclines.
- Tetracycline Hydrochloride + Antacids Containing Calcium— Antacids containing calcium impair absorption of tetracyclines.
- Tetracycline Hydrochloride + Antacids Containing Calcium, Magnesium, Or Aluminum— Antacids containing aluminum, calcium, or magnesium impair absorption of tetracycline.
- Tetracycline Hydrochloride + Antacids Containing Magnesium— Antacids containing magnesium impair absorption of tetracyclines.
- Tetracycline Hydrochloride + Iron Supplements— Iron preparations impair absorption of tetracycline.
- Tetracycline Hydrochloride + Iron-Containing Preparations— Impairs absorption of tetracyclines.
- Tetracycline Hydrochloride + Multivitamin Preparations With Zinc— Impairs absorption of tetracyclines.
- Tetracycline Hydrochloride + Oral Anticoagulants— Tetracyclines depress plasma prothrombin activity; patients may require downward adjustment of anticoagulant dosage.
- Tetracycline Hydrochloride + Oral Contraceptives— Concurrent use of tetracycline may render oral contraceptives less effective.
- Tetracycline Hydrochloride + Sodium Bicarbonate— Sodium bicarbonate impairs absorption of tetracycline.
- Tetracycline Hydrochloride + Steroid Therapy— Tetracycline depresses plasma prothrombin activity, requiring possible downward adjustment of anticoagulant dosage.
- Tetracycline Hydrochloride + Zinc— Zinc preparations impair absorption of tetracycline.