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Memantine Hydrochloride And Donepezil Hydrochloride

Also known as: Namzaric

Route: Oral

Check Memantine Hydrochloride And Donepezil Hydrochloride Interactions →

14 interactions on record

Memantine Hydrochloride And Donepezil Hydrochloride has 14 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Amantadine, Bethanechol, Carbamazepine. Patients taking Memantine Hydrochloride And Donepezil Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 14
Moderate: 14

Moderate (14)

Memantine Hydrochloride And Donepezil Hydrochloride + Amantadine— Combined use of memantine with amantadine (NMDA antagonist) has not been systematically evaluated and should be approach…
Memantine Hydrochloride And Donepezil Hydrochloride + Bethanechol— Concomitant use with bethanechol (cholinergic agonist) may lead to synergistic cholinergic effects due to donepezil's ch…
Memantine Hydrochloride And Donepezil Hydrochloride + Carbamazepine— Carbamazepine induces CYP3A4, potentially increasing the rate of elimination of donepezil.
Memantine Hydrochloride And Donepezil Hydrochloride + Dexamethasone— Dexamethasone induces CYP3A4, potentially increasing the rate of elimination of donepezil.
Memantine Hydrochloride And Donepezil Hydrochloride + Dextromethorphan— Combined use of memantine with dextromethorphan (NMDA antagonist) has not been systematically evaluated and should be ap…
Memantine Hydrochloride And Donepezil Hydrochloride + Ketamine— Combined use of memantine with ketamine (NMDA antagonist) has not been systematically evaluated and should be approached…
Memantine Hydrochloride And Donepezil Hydrochloride + Ketoconazole— Ketoconazole inhibits CYP3A4, which may increase donepezil levels in vitro; clinical significance unknown.
Memantine Hydrochloride And Donepezil Hydrochloride + Mao Inhibitors— Carbonic anhydrase inhibitors may alter urine pH towards alkaline conditions, reducing memantine clearance by about 80% …
Memantine Hydrochloride And Donepezil Hydrochloride + Phenobarbital— Phenobarbital induces CYP3A4, potentially increasing the rate of elimination of donepezil.
Memantine Hydrochloride And Donepezil Hydrochloride + Phenytoin— Phenytoin induces CYP3A4, potentially increasing the rate of elimination of donepezil.
Memantine Hydrochloride And Donepezil Hydrochloride + Quinidine— CYP2D6 inhibitor that inhibits donepezil metabolism in vitro; clinical effect not established.
Memantine Hydrochloride And Donepezil Hydrochloride + Rifampin— Rifampin induces CYP3A4, potentially increasing the rate of elimination of donepezil.
Memantine Hydrochloride And Donepezil Hydrochloride + Sodium Bicarbonate— Sodium bicarbonate may alter urine pH towards alkaline conditions, reducing memantine clearance by about 80% and leading…
Memantine Hydrochloride And Donepezil Hydrochloride + Succinylcholine— Concomitant use with succinylcholine may lead to synergistic cholinergic effects due to donepezil's cholinesterase inhib…

Memantine Hydrochloride And Donepezil Hydrochloride + Amantadine🟡Moderate

Combined use of memantine with amantadine (NMDA antagonist) has not been systematically evaluated and should be approached with caution.

Memantine Hydrochloride And Donepezil Hydrochloride + Bethanechol🟡Moderate

Concomitant use with bethanechol (cholinergic agonist) may lead to synergistic cholinergic effects due to donepezil's cholinesterase inhibition.

Memantine Hydrochloride And Donepezil Hydrochloride + Carbamazepine🟡Moderate

Carbamazepine induces CYP3A4, potentially increasing the rate of elimination of donepezil.

Memantine Hydrochloride And Donepezil Hydrochloride + Dexamethasone🟡Moderate

Dexamethasone induces CYP3A4, potentially increasing the rate of elimination of donepezil.

Memantine Hydrochloride And Donepezil Hydrochloride + Dextromethorphan🟡Moderate

Combined use of memantine with dextromethorphan (NMDA antagonist) has not been systematically evaluated and should be approached with caution.

Memantine Hydrochloride And Donepezil Hydrochloride + Ketamine🟡Moderate

Combined use of memantine with ketamine (NMDA antagonist) has not been systematically evaluated and should be approached with caution.

Memantine Hydrochloride And Donepezil Hydrochloride + Ketoconazole🟡Moderate

Ketoconazole inhibits CYP3A4, which may increase donepezil levels in vitro; clinical significance unknown.

Memantine Hydrochloride And Donepezil Hydrochloride + Mao Inhibitors🟡Moderate

Carbonic anhydrase inhibitors may alter urine pH towards alkaline conditions, reducing memantine clearance by about 80% and leading to drug accumulation.

Memantine Hydrochloride And Donepezil Hydrochloride + Phenobarbital🟡Moderate

Phenobarbital induces CYP3A4, potentially increasing the rate of elimination of donepezil.

Memantine Hydrochloride And Donepezil Hydrochloride + Phenytoin🟡Moderate

Phenytoin induces CYP3A4, potentially increasing the rate of elimination of donepezil.

Memantine Hydrochloride And Donepezil Hydrochloride + Quinidine🟡Moderate

CYP2D6 inhibitor that inhibits donepezil metabolism in vitro; clinical effect not established.

Memantine Hydrochloride And Donepezil Hydrochloride + Rifampin🟡Moderate

Rifampin induces CYP3A4, potentially increasing the rate of elimination of donepezil.

Memantine Hydrochloride And Donepezil Hydrochloride + Sodium Bicarbonate🟡Moderate

Sodium bicarbonate may alter urine pH towards alkaline conditions, reducing memantine clearance by about 80% and leading to drug accumulation.

Memantine Hydrochloride And Donepezil Hydrochloride + Succinylcholine🟡Moderate

Concomitant use with succinylcholine may lead to synergistic cholinergic effects due to donepezil's cholinesterase inhibition.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.