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Etonogestrel

Also known as: Nexplanon

Progestin

Route: Subcutaneous

35 interactions on record⛔ Black Box Warning

Etonogestrel has 35 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Amprenavir, Aprepitant, Atazanavir. Patients taking Etonogestrel should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 35
Moderate: 34

Moderate (34)

Etonogestrel + Amprenavir— HIV protease inhibitor combination that may decrease plasma concentrations of etonogestrel.
Etonogestrel + Aprepitant— May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough ble…
Etonogestrel + Atazanavir— HIV protease inhibitor combination that may increase plasma concentrations of etonogestrel.
Etonogestrel + Barbiturates— May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough ble…
Etonogestrel + Boceprevir— HCV protease inhibitor that may decrease plasma concentrations of etonogestrel.
Etonogestrel + Bosentan— May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough ble…
Etonogestrel + Carbamazepine— May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough ble…
Etonogestrel + Cyclosporine— Etonogestrel may increase plasma concentrations of cyclosporine.
Etonogestrel + Darunavir— HIV protease inhibitor combination that may decrease plasma concentrations of etonogestrel.
Etonogestrel + Efavirenz— May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough ble…
Etonogestrel + Etravirine— Non-nucleoside reverse transcriptase inhibitor that may increase plasma concentrations of etonogestrel.
Etonogestrel + Felbamate— May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough ble…
Etonogestrel + Fluconazole— Substances increasing the plasma concentrations of HCs: Co-administration of certain HCs and strong or moderate CYP3A4 i…
Etonogestrel + Fosamprenavir— HIV protease inhibitor combination that may decrease plasma concentrations of etonogestrel.
Etonogestrel + Grapefruit Juice— Strong CYP3A4 inhibitor that may increase serum concentrations of etonogestrel.
Etonogestrel + Griseofulvin— May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough ble…
Etonogestrel + Indinavir— HIV protease inhibitor that may increase plasma concentrations of etonogestrel.
Etonogestrel + Itraconazole— Substances increasing the plasma concentrations of HCs: Co-administration of certain HCs and strong or moderate CYP3A4 i…
Etonogestrel + Ketoconazole— Substances increasing the plasma concentrations of HCs: Co-administration of certain HCs and strong or moderate CYP3A4 i…
Etonogestrel + Lamotrigine— Etonogestrel may decrease plasma concentrations of lamotrigine.
Etonogestrel + Lopinavir And Ritonavir— HIV protease inhibitor combination that may decrease plasma concentrations of etonogestrel.
Etonogestrel + Nelfinavir— HIV protease inhibitor that may decrease plasma concentrations of etonogestrel.
Etonogestrel + Nevirapine— Non-nucleoside reverse transcriptase inhibitor that may decrease plasma concentrations of etonogestrel.
Etonogestrel + Oxcarbazepine— May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough ble…
Etonogestrel + Phenytoin— May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough ble…
Etonogestrel + Rifabutin— May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough ble…
Etonogestrel + Rifampin— May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough ble…
Etonogestrel + Ritonavir— HIV protease inhibitor that may decrease plasma concentrations of etonogestrel.
Etonogestrel + Rufinamide— May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough ble…
Etonogestrel + St. John'S Wort— May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough ble…
Etonogestrel + Telaprevir— HCV protease inhibitor that may decrease plasma concentrations of etonogestrel.
Etonogestrel + Tipranavir— HIV protease inhibitor combination that may decrease plasma concentrations of etonogestrel.
Etonogestrel + Topiramate— May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough ble…
Etonogestrel + Voriconazole— Substances increasing the plasma concentrations of HCs: Co-administration of certain HCs and strong or moderate CYP3A4 i…

Etonogestrel + Amprenavir🟡Moderate

HIV protease inhibitor combination that may decrease plasma concentrations of etonogestrel.

Etonogestrel + Aprepitant🟡Moderate

May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough bleeding.

Etonogestrel + Atazanavir🟡Moderate

HIV protease inhibitor combination that may increase plasma concentrations of etonogestrel.

Etonogestrel + Barbiturates🟡Moderate

May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough bleeding.

Etonogestrel + Boceprevir🟡Moderate

HCV protease inhibitor that may decrease plasma concentrations of etonogestrel.

Etonogestrel + Bosentan🟡Moderate

May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough bleeding.

Etonogestrel + Carbamazepine🟡Moderate

May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough bleeding.

Etonogestrel + Cyclosporine🟡Moderate

Etonogestrel may increase plasma concentrations of cyclosporine.

Etonogestrel + Darunavir🟡Moderate

HIV protease inhibitor combination that may decrease plasma concentrations of etonogestrel.

Etonogestrel + Efavirenz🟡Moderate

May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough bleeding.

Etonogestrel + Etravirine🟡Moderate

Non-nucleoside reverse transcriptase inhibitor that may increase plasma concentrations of etonogestrel.

Etonogestrel + Felbamate🟡Moderate

May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough bleeding.

Etonogestrel + Fluconazole🟡Moderate

Substances increasing the plasma concentrations of HCs: Co-administration of certain HCs and strong or moderate CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase the serum concentrations of progestins, including etonogestrel.

Etonogestrel + Fosamprenavir🟡Moderate

HIV protease inhibitor combination that may decrease plasma concentrations of etonogestrel.

Etonogestrel + Grapefruit Juice🟡Moderate

Strong CYP3A4 inhibitor that may increase serum concentrations of etonogestrel.

Etonogestrel + Griseofulvin🟡Moderate

May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough bleeding.

Etonogestrel + Indinavir🟡Moderate

HIV protease inhibitor that may increase plasma concentrations of etonogestrel.

Etonogestrel + Itraconazole🟡Moderate

Etonogestrel + Ketoconazole🟡Moderate

Etonogestrel + Lamotrigine🟡Moderate

Etonogestrel may decrease plasma concentrations of lamotrigine.

Etonogestrel + Lopinavir And Ritonavir🟡Moderate

HIV protease inhibitor combination that may decrease plasma concentrations of etonogestrel.

Etonogestrel + Nelfinavir🟡Moderate

HIV protease inhibitor that may decrease plasma concentrations of etonogestrel.

Etonogestrel + Nevirapine🟡Moderate

Non-nucleoside reverse transcriptase inhibitor that may decrease plasma concentrations of etonogestrel.

Etonogestrel + Oxcarbazepine🟡Moderate

May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough bleeding.

Etonogestrel + Phenytoin🟡Moderate

May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough bleeding.

Etonogestrel + Rifabutin🟡Moderate

May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough bleeding.

Etonogestrel + Rifampin🟡Moderate

May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough bleeding.

Etonogestrel + Ritonavir🟡Moderate

HIV protease inhibitor that may decrease plasma concentrations of etonogestrel.

Etonogestrel + Rufinamide🟡Moderate

May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough bleeding.

Etonogestrel + St. John'S Wort🟡Moderate

May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough bleeding.

Etonogestrel + Telaprevir🟡Moderate

HCV protease inhibitor that may decrease plasma concentrations of etonogestrel.

Etonogestrel + Tipranavir🟡Moderate

HIV protease inhibitor combination that may decrease plasma concentrations of etonogestrel.

Etonogestrel + Topiramate🟡Moderate

May decrease plasma concentrations of etonogestrel and diminish contraceptive effectiveness or increase breakthrough bleeding.

Etonogestrel + Voriconazole🟡Moderate

Etonogestrel + Lopinavirℹ️Unknown

Human Immunodeficiency Virus (HIV)/Hepatitis C Virus (HCV) protease inhibitors and non-nucleoside reverse transcriptase inhibitors: Significant changes (increase or decrease) in the plasma concentrations of progestin have been noted in cases of co-administration with HIV protease inhibitors (decrease [e.g., nelfinavir, ritonavir, darunavir/ritonavir, (fos)amprenavir/ritonavir, lopinavir/ritonavir, and tipranavir/ritonavir] or increase [e.g., indinavir and atazanavir/ritonavir])/HCV protease inhibitors (decrease [e.g., boceprevir and telaprevir]) or with non-nucleoside reverse transcriptase inhibitors (decrease [e.g., nevirapine, efavirenz] or increase [e.g., etravirine]).

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.