Simeprevir has 23 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Rilpivirine, Amiodarone Hydrochloride, Amlodipine And Atorvastatin. Patients taking Simeprevir should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 23
- Contraindicated
- 1
- Major
- 8
Contraindicated (1)
- Simeprevir + Rilpivirine— Proton Pump Inhibitors: e.g., esomeprazole lansoprazole omeprazole pantoprazole rabeprazole ↓ rilpivirine Coadministrati…
Major (8)
- Simeprevir + Amiodarone Hydrochloride— 7.3 Serious Symptomatic Bradycardia When Co-administered with Ledipasvir/Sofosbuvir or with Sofosbuvir with Simeprevir P…
- Simeprevir + Amlodipine And Atorvastatin— No drug interaction studies have been conducted with amlodipine besylate and atorvastatin calcium and other drugs, altho…
- Simeprevir + Atorvaliq— Significantly increases atorvastatin plasma levels. Consider risk/benefit of concomitant use.
- Simeprevir + Atorvastatin Calcium— 7 DRUG INTERACTIONS Drug Interactions that may Increase the Risk of Myopathy and Rhabdomyolysis with atorvastatin ( 2.6 …
- Simeprevir + Nexterone (Amiodarone Hci)— 7.3 Serious Symptomatic Bradycardia When Co-administered with Ledipasvir/Sofosbuvir or with Sofosbuvir with Simeprevir P…
- Simeprevir + Rifampin— Antiretrovirals Prevention or Management: Avoid concomitant use Zidovudine Decrease AUC by 47% Indinavir Decrease AUC by…
- Simeprevir + Rosuvastatin— Intervention: • Sofosbuvir/velpatasvir/voxilaprevir • Ledipasvir/sofosbuvir Avoid concomitant use with rosuvastatin • Si…
- Simeprevir + Rosuvastatin Calcium— Simeprevir increases rosuvastatin exposure up to 3-fold. Limit rosuvastatin dose to 10 mg once daily.