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Fomepizole

Also known as: Fomepizole

Antidote

Route: Intravenous

5 interactions on record

Fomepizole has 5 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alcohol. Patients taking Fomepizole should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 5
Major: 1

Major (1)

Fomepizole + Alcohol— Fomepizole reduces ethanol elimination by approximately 40% via alcohol dehydrogenase inhibition; ethanol reciprocally r…

Fomepizole + Alcohol⚠️Major

Fomepizole reduces ethanol elimination by approximately 40% via alcohol dehydrogenase inhibition; ethanol reciprocally reduces fomepizole elimination by approximately 50%.

Fomepizole + Carbamazepineℹ️Unknown

Reciprocal interactions may occur through cytochrome P450 system effects, though not studied.

Fomepizole + Cimetidineℹ️Unknown

Reciprocal interactions may occur through cytochrome P450 system effects, though not studied.

Fomepizole + Ketoconazoleℹ️Unknown

Reciprocal interactions may occur with concomitant use of fomepizole and drugs that increase or inhibit the cytochrome P450 system (e.g., phenytoin, carbamazepine, cimetidine, ketoconazole), though this has not been studied.

Fomepizole + Phenytoinℹ️Unknown

Reciprocal interactions may occur through cytochrome P450 system effects, though not studied.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.