Hydroxychloroquine Sulfate has 14 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cimetidine, Rifampin, Drugs Prolonging Qt Interval And Other Arrhythmogenic Drugs. Patients taking Hydroxychloroquine Sulfate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 14
- Contraindicated
- 2
- Major
- 4
- Moderate
- 8
Contraindicated (2)
- Hydroxychloroquine Sulfate + Cimetidine— Can inhibit metabolism of chloroquine, increasing plasma level; concomitant use should be avoided.
- Hydroxychloroquine Sulfate + Rifampin— Lack of efficacy of hydroxychloroquine reported with concurrent use; concomitant use should be avoided.
Major (4)
- Hydroxychloroquine Sulfate + Drugs Prolonging Qt Interval And Other Arrhythmogenic Drugs— PLAQUENIL prolongs QT interval; concomitant use with other QT-prolonging or arrhythmogenic drugs may increase risk of ve…
- Hydroxychloroquine Sulfate + Drugs That Prolong Qtc Interval— Increased risk of inducing ventricular arrhythmias when used concomitantly with hydroxychloroquine sulfate tablets.
- Hydroxychloroquine Sulfate + Mefloquine— Co-administration may increase the risk of convulsions as both drugs lower the convulsive threshold.
- Hydroxychloroquine Sulfate + Methotrexate— Combined use has not been studied and may increase the incidence of adverse effects.
Moderate (8)
- Hydroxychloroquine Sulfate + Ampicillin— Chloroquine significantly reduced the bioavailability of ampicillin in healthy volunteers.
- Hydroxychloroquine Sulfate + Antacids Containing Calcium— Antacids can reduce absorption of chloroquine; an interval of at least 4 hours between intake is recommended.
- Hydroxychloroquine Sulfate + Cyclosporine— Increased plasma cyclosporin levels were reported when co-administered with hydroxychloroquine sulfate.
- Hydroxychloroquine Sulfate + Digoxin— Concomitant use may result in increased serum digoxin levels; serum digoxin levels should be closely monitored.
- Hydroxychloroquine Sulfate + Insulin Human— Hydroxychloroquine sulfate may enhance hypoglycemic effects, requiring a decrease in insulin doses.
- Hydroxychloroquine Sulfate + Kaolin— Kaolin can reduce absorption of chloroquine; an interval of at least 4 hours between intake is recommended.
- Hydroxychloroquine Sulfate + Praziquantel— Chloroquine has been reported to reduce the bioavailability of praziquantel; cannot be ruled out for hydroxychloroquine.
- Hydroxychloroquine Sulfate + Remdesivir— Potential antagonism based on cell culture data; concomitant use is not recommended due to risk of reduced efficacy.