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Lidocaine 5%

Also known as: Lidocaine 5%

Amide Local AnestheticAntiarrhythmic

Route: Topical

33 interactions on record

Lidocaine 5% has 33 known drug interactions based on U.S. FDA drug labeling data. 32 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetaminophen, Acetazolamide, Articaine. Patients taking Lidocaine 5% should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 33
Major: 32
Moderate: 1

Major (32)

Lidocaine 5% + Acetaminophen— May cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Acetazolamide— Antibiotic class that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Articaine— Local anesthetic; concurrent use increases risk of methemoglobinemia and requires consideration of total absorbed amount…
Lidocaine 5% + Benzocaine— Local anesthetic; concurrent use increases risk of methemoglobinemia and requires consideration of total absorbed amount…
Lidocaine 5% + Bupivacaine— Local anesthetic; concurrent use increases risk of methemoglobinemia and requires consideration of total absorbed amount…
Lidocaine 5% + Chloroquine— Antimalarial that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Cyclophosphamide— Antineoplastic agent that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Dapsone— Antibiotic that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Flutamide— Antineoplastic agent that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Hydroxyurea— Antineoplastic agent that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Ifosfamide— Antineoplastic agent that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Mepivacaine— Local anesthetic; concurrent use increases risk of methemoglobinemia and requires consideration of total absorbed amount…
Lidocaine 5% + Metoclopramide— May cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Mexiletine— Class I antiarrhythmic; toxic effects are additive and potentially synergistic with lidocaine patch 5%.
Lidocaine 5% + Nitric Oxide— May cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Nitrofurantoin— Antibiotic that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Nitroglycerin— Nitrate that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Nitroprusside— Nitrite that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Nitrous Oxide— Nitrite that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Para-Aminosalicylic Acid— Antibiotic that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Phenobarbital— Anticonvulsant that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Phenytoin— Anticonvulsant that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Prilocaine— Local anesthetic; concurrent use increases risk of methemoglobinemia and requires consideration of total absorbed amount…
Lidocaine 5% + Primaquine— Antimalarial that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Procaine— Local anesthetic; concurrent use increases risk of methemoglobinemia and requires consideration of total absorbed amount…
Lidocaine 5% + Quinine— May cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Rasburicase— Antineoplastic agent that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Ropivacaine— Local anesthetic; concurrent use increases risk of methemoglobinemia and requires consideration of total absorbed amount…
Lidocaine 5% + Sulfasalazine— May cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
Lidocaine 5% + Tetracaine— Local anesthetic; concurrent use increases risk of methemoglobinemia and requires consideration of total absorbed amount…
Lidocaine 5% + Tocainide— Class I antiarrhythmic; toxic effects are additive and potentially synergistic with lidocaine patch 5%.
Lidocaine 5% + Valproate Sodium— Anticonvulsant that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Moderate (1)

Lidocaine 5% + Topical Local Anesthetics— When used concomitantly with other local anesthetic products, the total amount absorbed from all formulations must be co…

Lidocaine 5% + Acetaminophen⚠️Major

May cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Acetazolamide⚠️Major

Antibiotic class that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Articaine⚠️Major

Local anesthetic; concurrent use increases risk of methemoglobinemia and requires consideration of total absorbed amount.

Lidocaine 5% + Benzocaine⚠️Major

Local anesthetic; concurrent use increases risk of methemoglobinemia and requires consideration of total absorbed amount.

Lidocaine 5% + Bupivacaine⚠️Major

Local anesthetic; concurrent use increases risk of methemoglobinemia and requires consideration of total absorbed amount.

Lidocaine 5% + Chloroquine⚠️Major

Antimalarial that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Cyclophosphamide⚠️Major

Antineoplastic agent that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Dapsone⚠️Major

Antibiotic that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Flutamide⚠️Major

Antineoplastic agent that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Hydroxyurea⚠️Major

Antineoplastic agent that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Ifosfamide⚠️Major

Antineoplastic agent that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Mepivacaine⚠️Major

Local anesthetic; concurrent use increases risk of methemoglobinemia and requires consideration of total absorbed amount.

Lidocaine 5% + Metoclopramide⚠️Major

May cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Mexiletine⚠️Major

Class I antiarrhythmic; toxic effects are additive and potentially synergistic with lidocaine patch 5%.

Lidocaine 5% + Nitric Oxide⚠️Major

May cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Nitrofurantoin⚠️Major

Antibiotic that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Nitroglycerin⚠️Major

Nitrate that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Nitroprusside⚠️Major

Nitrite that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Nitrous Oxide⚠️Major

Nitrite that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Para-Aminosalicylic Acid⚠️Major

Antibiotic that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Phenobarbital⚠️Major

Anticonvulsant that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Phenytoin⚠️Major

Anticonvulsant that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Prilocaine⚠️Major

Local anesthetic; concurrent use increases risk of methemoglobinemia and requires consideration of total absorbed amount.

Lidocaine 5% + Primaquine⚠️Major

Antimalarial that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Procaine⚠️Major

Local anesthetic; concurrent use increases risk of methemoglobinemia and requires consideration of total absorbed amount.

Lidocaine 5% + Quinine⚠️Major

May cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Rasburicase⚠️Major

Antineoplastic agent that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Ropivacaine⚠️Major

Local anesthetic; concurrent use increases risk of methemoglobinemia and requires consideration of total absorbed amount.

Lidocaine 5% + Sulfasalazine⚠️Major

May cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Tetracaine⚠️Major

Local anesthetic; concurrent use increases risk of methemoglobinemia and requires consideration of total absorbed amount.

Lidocaine 5% + Tocainide⚠️Major

Class I antiarrhythmic; toxic effects are additive and potentially synergistic with lidocaine patch 5%.

Lidocaine 5% + Valproate Sodium⚠️Major

Anticonvulsant that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.

Lidocaine 5% + Topical Local Anesthetics🟡Moderate

When used concomitantly with other local anesthetic products, the total amount absorbed from all formulations must be considered to avoid toxicity.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.