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Eliglustat

Also known as: Cerdelga

Glucosylceramide Synthase InhibitorGlucosylceramide Synthase InhibitorsP-Glycoprotein Inhibitors

Route: Oral

Check Eliglustat Interactions →
6 interactions on record

Eliglustat has 6 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Itraconazole, Levoketoconazole, Mao Inhibitors. Patients taking Eliglustat should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total
6
Contraindicated
3
Moderate
3

Contraindicated (3)

  • Eliglustat + Itraconazole— Coadministration is contraindicated in poor or intermediate CYP2D6 metabolizers and in subjects taking strong or moderat…
  • Eliglustat + Levoketoconazole— Concomitant use is contraindicated in poor or intermediate CYP2D6 metabolizers and in patients taking CYP2D6 inhibitors …
  • Eliglustat + Mao Inhibitors— Strong CYP3A inhibitors are contraindicated in intermediate and poor CYP2D6 metabolizers due to increased eliglustat con…

Moderate (3)

  • Eliglustat + Anti-Platelet Agents— Eliglustat may increase concentrations of P-glycoprotein substrates, increasing toxicity risk. Monitor therapeutic conce…
  • Eliglustat + Cyp3a Inducers— Strong CYP3A inducers decrease eliglustat concentrations, which may reduce CERDELGA efficacy. Coadministration should be…
  • Eliglustat + Digoxin— Eliglustat may increase digoxin concentrations as a P-gp substrate. Monitor serum digoxin and reduce dose by 30% before …

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.