Does Eliglustat Interact with Levoketoconazole?
CDI records a contraindicated classification for Eliglustat and Levoketoconazole. The stored summary is: Concomitant use is contraindicated in poor or intermediate CYP2D6 metabolizers and in patients taking CYP2D6 inhibitors due to QT prolongation risk. The mechanism involves cyp3a4 substrate; qt prolongation risk. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Eliglustat Class
- Glucosylceramide Synthase Inhibitor
- Levoketoconazole Class
- Cortisol Synthesis Inhibitor
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP3A4 substrate; QT prolongation risk
What To Tell Your Doctor or Pharmacist
If you are taking Eliglustat and your doctor is considering prescribing Levoketoconazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider