Nintedanib has 8 known drug interactions based on U.S. FDA drug labeling data. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Carbamazepine, Oral Anticoagulants, Phenytoin. Patients taking Nintedanib should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 8
- Major
- 4
- Moderate
- 4
Major (4)
- Nintedanib + Carbamazepine— P-gp and CYP3A4 inducer that may decrease nintedanib exposure. Should be avoided due to risk of reduced efficacy.
- Nintedanib + Oral Anticoagulants— Nintedanib is a VEGFR inhibitor that may increase bleeding risk. Monitor patients on full anticoagulation therapy closel…
- Nintedanib + Phenytoin— P-gp and CYP3A4 inducer that may decrease nintedanib exposure. Should be avoided due to risk of reduced efficacy.
- Nintedanib + St. John'S Wort— P-gp and CYP3A4 inducer that may decrease nintedanib exposure. Should be avoided due to risk of reduced efficacy.
Moderate (4)
- Nintedanib + Erythromycin— P-gp and CYP3A4 inhibitor that may increase nintedanib exposure. Monitor patients closely for tolerability.
- Nintedanib + Itraconazole— Bortezomib Brentuximab vedotin Busulfan a Erlotinib Gefitinib a Idelalisib Imatinib Ixabepilone Nintedanib Panobinostat …
- Nintedanib + Ketoconazole— P-gp and CYP3A4 inhibitor that increased nintedanib exposure by 60%. Monitor patients closely for tolerability.
- Nintedanib + Rifampin— P-gp and CYP3A4 inducer that decreased nintedanib exposure by 50%. May reduce nintedanib efficacy.