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Dicumarol

7 interactions on record

Dicumarol has 7 known drug interactions based on U.S. FDA drug labeling data. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Allopurinol, Heparin Sodium, Phenobarbital. Patients taking Dicumarol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 7
Major: 4
Moderate: 3

Major (4)

Dicumarol + Allopurinol— Allopurinol prolongs the half-life of anticoagulant dicumarol.
Dicumarol + Heparin Sodium— Heparin may prolong prothrombin time; at least 5 hours after IV or 24 hours after SC heparin dose should elapse before b…
Dicumarol + Phenobarbital— Phenobarbital lowers plasma levels of dicumarol and decreases anticoagulant activity. Induction of hepatic microsomal en…
Dicumarol + Phenobarbital Sodium— Phenobarbital lowers plasma levels of dicumarol and decreases anticoagulant activity. Barbiturates induce hepatic micros…

Moderate (3)

Dicumarol + Dicloxacillin Sodium— Dicloxacillin may reduce the anticoagulant response to dicumarol; careful monitoring of prothrombin times is suggested a…
Dicumarol + Glipizide— In vitro binding studies suggest limited interaction, but caution is advised in clinical use.
Dicumarol + Pentobarbital Sodium— Barbiturates lower plasma levels and decrease anticoagulant activity. Dosage adjustments may be needed when barbiturates…

Dicumarol + Allopurinol⚠️Major

Allopurinol prolongs the half-life of anticoagulant dicumarol.

Dicumarol + Heparin Sodium⚠️Major

Heparin may prolong prothrombin time; at least 5 hours after IV or 24 hours after SC heparin dose should elapse before blood draw for valid PT.

Dicumarol + Phenobarbital⚠️Major

Phenobarbital lowers plasma levels of dicumarol and decreases anticoagulant activity. Induction of hepatic microsomal enzymes increases metabolism and reduces anticoagulant response.

Dicumarol + Phenobarbital Sodium⚠️Major

Phenobarbital lowers plasma levels of dicumarol and decreases anticoagulant activity. Barbiturates induce hepatic microsomal enzymes resulting in increased metabolism and decreased anticoagulant response.

Dicumarol + Dicloxacillin Sodium🟡Moderate

Dicloxacillin may reduce the anticoagulant response to dicumarol; careful monitoring of prothrombin times is suggested and dosage adjustment may be needed.

Dicumarol + Glipizide🟡Moderate

In vitro binding studies suggest limited interaction, but caution is advised in clinical use.

Dicumarol + Pentobarbital Sodium🟡Moderate

Barbiturates lower plasma levels and decrease anticoagulant activity. Dosage adjustments may be needed when barbiturates are added or withdrawn.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.