Dicumarol has 7 known drug interactions based on U.S. FDA drug labeling data. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Allopurinol, Heparin Sodium, Phenobarbital. Patients taking Dicumarol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 7
- Major
- 4
- Moderate
- 3
Major (4)
- Dicumarol + Allopurinol— Allopurinol prolongs the half-life of anticoagulant dicumarol.
- Dicumarol + Heparin Sodium— Heparin may prolong prothrombin time; at least 5 hours after IV or 24 hours after SC heparin dose should elapse before b…
- Dicumarol + Phenobarbital— Phenobarbital lowers plasma levels of dicumarol and decreases anticoagulant activity. Induction of hepatic microsomal en…
- Dicumarol + Phenobarbital Sodium— Phenobarbital lowers plasma levels of dicumarol and decreases anticoagulant activity. Barbiturates induce hepatic micros…
Moderate (3)
- Dicumarol + Dicloxacillin Sodium— Dicloxacillin may reduce the anticoagulant response to dicumarol; careful monitoring of prothrombin times is suggested a…
- Dicumarol + Glipizide— In vitro binding studies suggest limited interaction, but caution is advised in clinical use.
- Dicumarol + Pentobarbital Sodium— Barbiturates lower plasma levels and decrease anticoagulant activity. Dosage adjustments may be needed when barbiturates…