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Bleomycin Sulfate

Also known as: Bleomycin

Route: Intramuscular, Intrapleural, Intravenous, Subcutaneous

2 interactions on record⛔ Black Box Warning

Bleomycin Sulfate has 2 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cisplatin. Patients taking Bleomycin Sulfate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 2
Major: 1

Major (1)

Bleomycin Sulfate + Cisplatin— Nephrotoxic cisplatin decreases bleomycin renal clearance and increases half-life. Fatal pulmonary toxicity reported in …

Bleomycin Sulfate + Cisplatin⚠️Major

Nephrotoxic cisplatin decreases bleomycin renal clearance and increases half-life. Fatal pulmonary toxicity reported in patient with cisplatin-induced renal failure.

Bleomycin Sulfate + Bleomycinℹ️Unknown

Drug Interactions Drugs that Can Affect Renal Clearance Because bleomycin is eliminated predominantly through renal excretion, the administration of nephrotoxic drugs with bleomycin may affect its renal clearance. Specifically, in one report of 2 children receiving concomitant cisplatin with bleomycin, total body clearance of bleomycin decreased from 39 to 18 mL/min/m 2 as the cumulative dose of cisplatin exceeded 300 mg/m 2 . Terminal half-life of bleomycin also increased from 4.4 to 6 hours.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.