Bleomycin has 9 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Allopurinol, Cisplatin, Ascorbic Acid. Patients taking Bleomycin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 9
- Major
- 2
- Moderate
- 6
Major (2)
- Bleomycin + Allopurinol— Increases bone marrow suppression in patients with neoplastic disease (except leukemia). Blood count monitoring recommen…
- Bleomycin + Cisplatin— Nephrotoxic cisplatin decreases bleomycin renal clearance and increases half-life. Fatal bleomycin pulmonary toxicity re…
Moderate (6)
- Bleomycin + Ascorbic Acid— Bleomycin is inactivated by ascorbic acid. Standard monitoring of antibiotic efficacy is warranted.
- Bleomycin + Ascorbic Acid, Vitamin A Palmitate, Cholecalciferol, Thiamine Hydrochloride, Riboflavin-5 Phosphate Sodium, Pyridoxine Hydrochloride, Niacinamide, Dexpanthenol, Alpha-Tocopherol Acetate, Vitamin K1, Folic Acid, Biotin, Cyanocobalamin— Ascorbic acid and riboflavin may inactivate bleomycin in vitro, reducing its activity.
- Bleomycin + Fosphenytoin Sodium— May decrease phenytoin serum levels; dose adjustment may be required.
- Bleomycin + Multiple Vitamins Injection— Ascorbic acid and riboflavin may inactivate bleomycin and reduce its activity.
- Bleomycin + Phenytoin— May decrease phenytoin serum levels; monitoring of phenytoin levels recommended.
- Bleomycin + Phenytoin Sodium— May decrease phenytoin serum levels; monitoring of phenytoin levels recommended.