Fludrocortisone Acetate has 17 known drug interactions based on U.S. FDA drug labeling data. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amphotericin B, Chlorothiazide, Digitalis Glycosides. Patients taking Fludrocortisone Acetate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 17
- Major
- 7
- Moderate
- 10
Major (7)
- Fludrocortisone Acetate + Amphotericin B— Enhanced hypokalemia. Requires frequent serum potassium monitoring and potassium supplementation.
- Fludrocortisone Acetate + Chlorothiazide— Potassium-depleting diuretics cause enhanced hypokalemia. Monitor serum potassium levels and use potassium supplements i…
- Fludrocortisone Acetate + Digitalis Glycosides— Enhanced possibility of arrhythmias or digitalis toxicity associated with hypokalemia. Monitor serum potassium levels an…
- Fludrocortisone Acetate + Ethacrynic Acid— Potassium-depleting diuretic causes enhanced hypokalemia. Monitor serum potassium levels and use potassium supplements i…
- Fludrocortisone Acetate + Furosemide— Potassium-depleting diuretic causes enhanced hypokalemia. Monitor serum potassium levels and use potassium supplements i…
- Fludrocortisone Acetate + Midodrine Hydrochloride— Concomitant use increases potential for supine hypertension. Monitor closely and may minimize by reducing fludrocortison…
- Fludrocortisone Acetate + Vaccines— Neurological complications and lack of antibody response may occur.
Moderate (10)
- Fludrocortisone Acetate + Acetylsalicylic Acid— Increased ulcerogenic effect and decreased pharmacologic effect of aspirin. Risk of salicylate toxicity upon steroid dis…
- Fludrocortisone Acetate + Barbiturates— Increased metabolic clearance of fludrocortisone acetate due to hepatic enzyme induction. May require increased steroid …
- Fludrocortisone Acetate + Estrogens— Increased levels of corticosteroid-binding globulin increasing bound inactive fraction. May require reduction in cortico…
- Fludrocortisone Acetate + Insulin Human— Diminished antidiabetic effect. Monitor for hyperglycemia and adjust insulin dosage upward if necessary.
- Fludrocortisone Acetate + Methandrostenolone— Enhanced tendency toward edema. Use caution, especially in patients with hepatic or cardiac disease.
- Fludrocortisone Acetate + Norethandrolone— Enhanced tendency toward edema. Use caution, especially in patients with hepatic or cardiac disease.
- Fludrocortisone Acetate + Oral Anticoagulants— Decreased prothrombin time response. Monitor prothrombin levels and adjust anticoagulant dosage accordingly.
- Fludrocortisone Acetate + Oxymetholone— Enhanced tendency toward edema. Use caution, especially in patients with hepatic or cardiac disease.
- Fludrocortisone Acetate + Phenytoin— Increased metabolic clearance of fludrocortisone acetate due to hepatic enzyme induction. May require increased steroid …
- Fludrocortisone Acetate + Rifampin— Increased metabolic clearance of fludrocortisone acetate due to hepatic enzyme induction. May require increased steroid …