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Brexpiprazole

Also known as: Brexpiprazole

Atypical Antipsychotic

Route: Oral

6 interactions on record⛔ Black Box Warning

Brexpiprazole has 6 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Fluoxetine, Paroxetine. Patients taking Brexpiprazole should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 6
Moderate: 2

Moderate (2)

Brexpiprazole + Fluoxetine— Strong CYP2D6 inhibitor that increases brexpiprazole exposure. Dosage adjustment may be needed depending on clinical con…
Brexpiprazole + Paroxetine— Strong CYP2D6 inhibitor that increases brexpiprazole exposure. Dosage adjustment may be needed depending on clinical con…

Brexpiprazole + Fluoxetine🟡Moderate

Strong CYP2D6 inhibitor that increases brexpiprazole exposure. Dosage adjustment may be needed depending on clinical context.

Brexpiprazole + Paroxetine🟡Moderate

Strong CYP2D6 inhibitor that increases brexpiprazole exposure. Dosage adjustment may be needed depending on clinical context.

Brexpiprazole + Lovastatinℹ️Unknown

Additionally, no dosage adjustment for substrates of CYP2D6 (e.g., dextromethorphan), CYP3A4 (e.g., lovastatin), CYP2B6 (e.g., bupropion), BCRP (e.g., rosuvastatin), or P-gp (e.g., fexofenadine) is required when administered concomitantly with REXULTI.

Brexpiprazole + Nirmatrelvir And Ritonavirℹ️Unknown

aripiprazole, brexpiprazole, cariprazine, iloperidone, lumateperone, pimavanserin ↑ aripiprazole ↑ brexpiprazole ↑ cariprazine ↑ iloperidone ↑ lumateperone ↑ pimavanserin Dosage adjustment of aripiprazole, brexpiprazole, cariprazine, iloperidone, lumateperone, and pimavanserin is recommended.

Brexpiprazole + Omeprazoleℹ️Unknown

7.2 Drugs Having No Clinically Important Interactions with REXULTI Based on pharmacokinetic studies, no dosage adjustment of REXULTI is required when administered concomitantly with CYP2B6 inhibitors (e.g., ticlopidine) or gastric pH modifiers (e.g., omeprazole).

Brexpiprazole + Rosuvastatinℹ️Unknown

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.