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Isavuconazole

9 interactions on record

Isavuconazole has 9 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Itraconazole, Tacrolimus, Darunavir. Patients taking Isavuconazole should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 9
Contraindicated: 1
Major: 1
Moderate: 7

Contraindicated (1)

Isavuconazole + Itraconazole— Coadministration is contraindicated. Itraconazole increases plasma concentrations, potentially increasing pharmacologic …

Major (1)

Isavuconazole + Tacrolimus— Mild or Moderate CYP3A Inhibitors, such as: antibiotics (e.g., erythromycin), calcium channel blockers (e.g., verapamil,…

Moderate (7)

Isavuconazole + Darunavir— Other: trazodone ↑ trazodone Antifungals: itraconazole, isavuconazole, ketoconazole, posaconazole ↑ darunavir ↑ itracona…
Isavuconazole + Darunavir 600 Mg— Antifungals: itraconazole, isavuconazole, ketoconazole, posaconazole voriconazole ↑ darunavir ↑ itraconazole ↑ isavucona…
Isavuconazole + Darunavir Ethanolate And Cobicistat— amitriptyline, desipramine, imipramine, nortriptyline ↑ TCAs Other antidepressants: trazodone ↑ trazodone Antifungals: i…
Isavuconazole + Darunavir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide— Tricyclic Antidepressants (TCAs): e.g., amitriptyline, desipramine, imipramine, nortriptyline ↑ TCAs Other antidepressan…
Isavuconazole + Isavuconazonium Sulfate— 7 DRUG INTERACTIONS Isavuconazole is a sensitive substrate of CYP3A4. CYP3A4 inhibitors or inducers may alter the plasma…
Isavuconazole + Mycophenolate Mofetil— Prevention or Management Monitor patients for alterations in efficacy or mycophenolate mofetil related adverse reactions…
Isavuconazole + Mycophenolate Mofetil Hydrochloride— Inhibits glucuronidation, increasing mycophenolic acid systemic exposure and potentially increasing risk of Mycophenolat…

Isavuconazole + Itraconazole⛔Contraindicated

Coadministration is contraindicated. Itraconazole increases plasma concentrations, potentially increasing pharmacologic effects and adverse reactions.

Isavuconazole + Tacrolimus⚠️Major

Mild or Moderate CYP3A Inhibitors, such as: antibiotics (e.g., erythromycin), calcium channel blockers (e.g., verapamil, diltiazem, nifedipine, nicardipine), amiodarone, danazol, ethinyl estradiol, cimetidine, lansoprazole and omeprazole, azole antifungals (e.g., clotrimazole, fluconazole, isavuconazole), imatinib, nilotinib, letermovir May increase tacrolimus whole blood trough concentrations and increase the risk of serious adverse reactions (e.g., neurotoxicity, QT prolongation) [see Warnings and Precautions (5.6 , 5.9 , 5.10) ].

Isavuconazole + Darunavir🟡Moderate

Other: trazodone ↑ trazodone Antifungals: itraconazole, isavuconazole, ketoconazole, posaconazole ↑ darunavir ↑ itraconazole ↑ isavuconazole ↑ ketoconazole ↔ posaconazole Monitor for increased darunavir/ritonavir and/or antifungal adverse events with concomitant use of these antifungals.

Isavuconazole + Darunavir 600 Mg🟡Moderate

Antifungals: itraconazole, isavuconazole, ketoconazole, posaconazole voriconazole ↑ darunavir ↑ itraconazole ↑ isavuconazole ↑ ketoconazole ↔ posaconazole ↓ voriconazole Monitor for increased darunavir/ritonavir and/or antifungal adverse events with concomitant use of these antifungals.

Isavuconazole + Darunavir Ethanolate And Cobicistat🟡Moderate

amitriptyline, desipramine, imipramine, nortriptyline ↑ TCAs Other antidepressants: trazodone ↑ trazodone Antifungals: itraconazole, isavuconazole, ketoconazole, posaconazole ↑ darunavir ↑ cobicistat Monitor for increased darunavir or cobicistat and/or antifungal adverse reactions. ↑ itraconazole ↑ ketoconazole ↑ isavuconazole ↔ posaconazole Specific dosing recommendations are not available for co-administration with these antifungals.

Isavuconazole + Darunavir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide🟡Moderate

Tricyclic Antidepressants (TCAs): e.g., amitriptyline, desipramine, imipramine, nortriptyline ↑ TCAs Other antidepressants: trazodone ↑ trazodone Antifungals: itraconazole, isavuconazole, ketoconazole, posaconazole ↑ darunavir ↑ cobicistat Monitor for increased darunavir or cobicistat and/or antifungal adverse reactions. ↑ itraconazole ↑ isavuconazole ↑ ketoconazole ↔ posaconazole (not studied) Specific dosing recommendations are not available for co-administration with these antifungals.

Isavuconazole + Isavuconazonium Sulfate🟡Moderate

7 DRUG INTERACTIONS Isavuconazole is a sensitive substrate of CYP3A4. CYP3A4 inhibitors or inducers may alter the plasma concentrations of isavuconazole. Isavuconazole is a moderate inhibitor of CYP3A4, and a mild inhibitor of P-glycoprotein (P-gp), and organic cation transporter 2 (OCT2).

Isavuconazole + Mycophenolate Mofetil🟡Moderate

Prevention or Management Monitor patients for alterations in efficacy or mycophenolate mofetil related adverse reactions when these drugs are co-administered with mycophenolate mofetil Examples Telmisartan (induces glucuronidation); isavuconazole (inhibits glucuronidation).

Isavuconazole + Mycophenolate Mofetil Hydrochloride🟡Moderate

Inhibits glucuronidation, increasing mycophenolic acid systemic exposure and potentially increasing risk of Mycophenolate Mofetil adverse reactions. Monitor for alterations.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.